Tailoring to RB: tumour suppressor status and therapeutic response

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

2004 • 5,895 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer

2006 • 2,484 citations

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

2003 • 2,104 citations

Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

2006 • 2,001 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

2006 • 1,867 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

To cycle or not to cycle: a critical decision in cancer

2001 • 1,429 citations

Senescence in premalignant tumours

2005 • 1,394 citations

The Concept of Synthetic Lethality in the Context of Anticancer Therapy

2005 • 1,324 citations

Hepatogastroenterology

2011 • 1,309 citations

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

2003 • 1,184 citations

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

2004 • 1,165 citations

Oncogene-induced senescence as an initial barrier in lymphoma development

2005 • 1,153 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

2006 • 1,135 citations

The Rb/E2F pathway: expanding roles and emerging paradigms

2000 • 1,125 citations

E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

2002 • 1,102 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

The Rb/E2F pathway and cancer

2001 • 913 citations

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

2006 • 911 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade

2007 • 818 citations

Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

2006 • 803 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Cyclin D-dependent kinases, INK4 inhibitors and cancer

2002 • 770 citations

The retinoblastoma tumour suppressor in development and cancer

2002 • 736 citations

The E2F transcriptional network: old acquaintances with new faces

2005 • 705 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

The ARF/p53 pathway

2000 • 647 citations

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

2001 • 592 citations

Pocket proteins and cell cycle control

2005 • 592 citations

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

2001 • 587 citations

Inactivation of the p53 pathway in retinoblastoma

2006 • 577 citations

Development of the 21-Gene Assay and Its Application in Clinical Practice and Clinical Trials

2008 • 559 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

Cycling to Cancer with Cyclin D1

2002 • 462 citations

Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis

2006 • 456 citations

Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6

2005 • 455 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

A revised picture of the E2F transcriptional network and RB function

2002 • 422 citations

Direct coupling of the cell cycle and cell death machinery by E2F

2002 • 419 citations

Putting the stress on senescence

2001 • 407 citations

Cyclin D1 in Breast Cancer Pathogenesis

2005 • 395 citations

Control of pRB phosphorylation

1998 • 389 citations

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

2007 • 387 citations

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

2000 • 384 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Genetic Origin of Mutations Predisposing to Retinoblastoma

1985 • 363 citations

Cyclin D1: polymorphism, aberrant splicing and cancer risk

2006 • 360 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

Retinoblastoma protein partners

2001 • 348 citations

AR, the cell cycle, and prostate cancer

2008 • 319 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

Elevated and Absent pRb Expression is Associated With Bladder Cancer Progression and has Cooperative Effects With p53

1998 • 317 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

1999 • 312 citations

Genetics of hepatocellular tumors

2006 • 310 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1995 • 294 citations

Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

1997 • 293 citations

Life and death decisions by the E2F transcription factors

2007 • 290 citations

Coordinated regulation of life and death by RB

2003 • 290 citations

Androgens Induce Prostate Cancer Cell Proliferation through Mammalian Target of Rapamycin Activation and Post-transcriptional Increases in Cyclin D Proteins

2006 • 289 citations

Molecular Pathways in Invasive Bladder Cancer: New Insights Into Mechanisms, Progression, and Target Identification

2006 • 280 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

2004 • 279 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

2004 • 277 citations

Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.

2003 • 269 citations

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis.

1997 • 260 citations

Combined Effects of p53, p21, and pRb Expression in the Progression of Bladder Transitional Cell Carcinoma

2004 • 258 citations

Molecular prognostic markers in pancreatic cancer: A systematic review

2005 • 256 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

A gene-expression signature to predict survival in breast cancer across independent data sets

2006 • 252 citations

Cyclins and Breast Cancer

2004 • 251 citations

Progression in Cutaneous Malignant Melanoma Is Associated with Distinct Expression Profiles

2004 • 241 citations

Cyclin D1 in Breast Cancer

1998 • 241 citations

pRB plays an essential role in cell cycle arrest induced by DNA damage

1998 • 238 citations

K-ras and p16 Aberrations Confer Poor Prognosis in Human Colorectal Cancer

2001 • 236 citations

Rb and p16INK4a expression in resected non-small cell lung tumors.

1996 • 236 citations

[Molecular abnormalities in lung cancer].

2002 • 233 citations

RB-Dependent S-Phase Response to DNA Damage

2000 • 224 citations

Management of Small Cell Lung Cancer

2007 • 220 citations

Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone.

2000 • 218 citations

Cell type-specific effects of Rb deletion in the murine retina

2004 • 217 citations

Risk of Soft Tissue Sarcomas by Individual Subtype in Survivors of Hereditary Retinoblastoma

2007 • 216 citations

The Petinoblastoma Tumor Suppressor Protein

1994 • 215 citations

Abrogated Response to Cellular Stress Identifies DCIS Associated with Subsequent Tumor Events and Defines Basal-like Breast Tumors

2007 • 213 citations

Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma.

2000 • 210 citations

Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay

2006 • 204 citations

pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation

1999 • 199 citations

Multiple G1 Regulatory Elements Control the Androgen-dependent Proliferation of Prostatic Carcinoma Cells

1998 • 197 citations

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer

2006 • 191 citations

D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability.

1999 • 187 citations

Multifaceted Regulation of Cell Cycle Progression by Estrogen: Regulation of Cdk Inhibitors and Cdc25A Independent of Cyclin D1-Cdk4 Function

2001 • 185 citations

Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner

2001 • 182 citations

Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation.

1995 • 179 citations

Development and Clinical Utility of a 21-Gene Recurrence Score Prognostic Assay in Patients with Early Breast Cancer Treated with Tamoxifen

2007 • 176 citations

Genome-scale profiling of gene expression in hepatocellular carcinoma: Classification, survival prediction, and identification of therapeutic targets

2004 • 174 citations

Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients

2004 • 160 citations

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.

1995 • 158 citations

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context

2006 • 155 citations

Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis

1994 • 149 citations

RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer

2002 • 148 citations

K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16INK4A, p21WAF-1, cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma

2000 • 147 citations

Cyclin D1: Mechanism and Consequence of Androgen Receptor Co-repressor Activity

2002 • 143 citations

Distinct regions of allelic loss on 13q in prostate cancer.

1996 • 140 citations

E2F-associated chromatin modifiers and cell cycle control

2007 • 140 citations

Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1

2006 • 138 citations

Cell cycle control and cancer.

2002 • 135 citations

Location, location, location: The role of cyclin D1 nuclear localization in cancer

2005 • 134 citations

Hitting their targets: an emerging picture of E2F and cell cycle control

2004 • 134 citations

Tumor Suppressor Genes in Breast Cancer

2005 • 133 citations

Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

1995 • 129 citations

Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers

2004 • 129 citations

Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo

2006 • 127 citations

Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China.

1994 • 125 citations

Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma

1997 • 124 citations

Identification of Target Genes of the p16INK4A-pRB-E2F Pathway

2003 • 124 citations

Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells

1994 • 124 citations

Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells

1998 • 123 citations

The transcription factor E2F-1 mediates the autoregulation of RB gene expression

1994 • 122 citations

Cyclin D1 protein expression and gene polymorphism in colorectal cancer

2000 • 121 citations

The role of human papillomaviruses in human cancers

2002 • 121 citations

INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis.

2000 • 119 citations

Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action.

2002 • 119 citations

Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage

2003 • 114 citations

Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells.

2002 • 112 citations

Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and histopathological parameters

1998 • 112 citations

Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment

2002 • 109 citations

Disruption of the p16/Cyclin D1/Retinoblastoma Protein Pathway in the Majority of Human Hepatocellular Carcinomas

2001 • 107 citations

RB in Breast Cancer: The Crossroads of Tumorigenesis and Treatment

2007 • 106 citations

Recapitulation of the Effects of the Human Papillomavirus Type 16 E7 Oncogene on Mouse Epithelium by Somatic Rb Deletion and Detection of pRb-Independent Effects of E7 In Vivo

2003 • 105 citations

New roles for the RB tumor suppressor protein

2003 • 104 citations

Liver-Specific pRB Loss Results in Ectopic Cell Cycle Entry and Aberrant Ploidy

2005 • 102 citations

Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis

2007 • 102 citations

Cyclin D1 expression in papillary superficial bladder cancer: Its association with other cell cycle‐associated proteins, cell proliferation and clinical outcome

2001 • 101 citations

Role of pRB dephosphorylation in cell cycle regulation

2000 • 101 citations

FISH Analysis of Gene Aberrations (MYC, CCND1, ERBB2, RB, and AR) in Advanced Prostatic Carcinomas Before and After Androgen Deprivation Therapy

2000 • 97 citations

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

2004 • 96 citations

Perturbation of cell cycle regulators in human cancer.

1996 • 96 citations

Prognostic and Predictive Effects of Immunohistochemical Factors in High-Risk Primary Breast Cancer Patients

2006 • 95 citations

Prognostic molecular markers in non-small cell lung cancer

2001 • 94 citations

Identification of two distinct deleted regions on chromosome 13 in prostate cancer

1998 • 94 citations

Cyclin D1 Expression in Breast Cancer Patients Receiving Adjuvant Tamoxifen-Based Therapy

2008 • 92 citations

Rb family proteins differentially regulate distinct cell lineages during epithelial development

2004 • 90 citations

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

2008 • 89 citations

p16INK4a is a Prognostic Marker in Resected Ductal Pancreatic Cancer

2002 • 88 citations

Analysis of key cell‐cycle checkpoint proteins in colorectal tumours

2002 • 87 citations

Elevated and Absent pRb Expression is Associated With Bladder Cancer Progression and has Cooperative Effects With p53

1998 • 87 citations

Value of p16 INK4a and RASSF1A Promoter Hypermethylation in Prognosis of Patients with Resectable Non–Small Cell Lung Cancer

2004 • 86 citations

Expression of p16 and lack of pRB in primary small cell lung cancer

1999 • 86 citations

The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma

1997 • 85 citations

Retinoblastoma family proteins: insights gained through genetic manipulation of mice

2006 • 85 citations

RB Loss Abrogates Cell Cycle Control and Genome Integrity to Promote Liver Tumorigenesis

2007 • 84 citations

Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas

1996 • 84 citations

Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67

2001 • 84 citations

Retinoblastoma Tumor Suppressor Status Is a Critical Determinant of Therapeutic Response in Prostate Cancer Cells

2007 • 83 citations

Retinoblastoma Tumor Suppressor Targets dNTP Metabolism to Regulate DNA Replication

2002 • 82 citations

Differential Inactivation of CDKN2 and Rb Protein in Non--Small-Cell and Small-Cell Lung Cancer Cell Lines

1995 • 82 citations

Proliferation: the Most Prominent Predictor of Clinical Outcome in Breast Cancer

2006 • 82 citations

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

1996 • 81 citations

Small Molecule Inhibition of HDM2 Leads to p53-Mediated Cell Death in Retinoblastoma Cells

2006 • 77 citations

p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

1997 • 77 citations

Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function

2007 • 76 citations

Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma.

1997 • 75 citations

Reversing Drug Resistance In Vivo

2004 • 74 citations

The cyclin D1b splice variant: an old oncogene learns new tricks.

2006 • 74 citations

Molecular prognostication of liver cancer: End of the beginning

2006 • 74 citations

Impact of differential cyclin D1 expression and localisation in prostate cancer

2007 • 73 citations

Distinct gene expression phenotypes of cells lacking Rb and Rb family members.

2003 • 72 citations

Allelic loss on chromosome 13q in human prostate carcinoma.

1997 • 72 citations

G1‐S transition defects occur in most breast cancers and predict outcome

1999 • 70 citations

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In Vivo

2005 • 70 citations

Expression of cyclin D1, Ki-67 and PCNA in non-small cell lung cancer: prognostic significance and comparison with p53 and bcl-2

2000 • 68 citations

Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival

1995 • 68 citations

Phase I Trial of the Cyclin-Dependent Kinase Inhibitor Flavopiridol in Combination with Docetaxel in Patients with Metastatic Breast Cancer

2004 • 67 citations

A multimarker model to predict outcome in tamoxifen-treated breast cancer patients.

2006 • 65 citations

A Phase II Clinical and Pharmacodynamic Study of E7070 in Patients with Metastatic, Recurrent, or Refractory Squamous Cell Carcinoma of the Head and Neck

2004 • 63 citations

ARF Is Not Required for Apoptosis in Rb Mutant Mouse Embryos

2002 • 63 citations

Cytogenetics and molecular cytogenetics in multiple myeloma

2006 • 62 citations

A Gradient of Epidermal Growth Factor Receptor Signaling Determines the Sensitivity of rbf1 Mutant Cells to E2F-Dependent Apoptosis

2006 • 62 citations

Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression

2006 • 62 citations

Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence

2003 • 59 citations

Overexpression of cyclin D1 is rare in human prostate carcinoma

1999 • 59 citations

UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent

1999 • 58 citations

p16INK4A expression in cervical premalignant and malignant lesions

2005 • 57 citations

Alterations in the p16/pRb cell cycle checkpoint occur commonly in primary and metastatic human prostate cancer

2002 • 53 citations

Prognostic Value of p16 in Locally Advanced Prostate Cancer: A Study Based on Radiation Therapy Oncology Group Protocol 9202

2007 • 52 citations

Expression of E6/E7 mRNA from ‘high risk’ human papillomavirus in relation to CIN grade, viral load and p16INK4a

2006 • 51 citations

Somatic cell type specific gene transfer reveals a tumor-promoting function for p21Waf1/Cip1

2007 • 51 citations

Loss of Retinoblastoma Tumor Suppressor Protein Makes Human Breast Cancer Cells More Sensitive to Antimetabolite Exposure

2008 • 51 citations

RB activation defect in tumor cell lines

2002 • 47 citations

Prognostic significance of molecular alterations in human pancreatic carcinoma – an immunohistological study

1998 • 46 citations

Targeting MDM2 and MDMX in Retinoblastoma

2007 • 44 citations

RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma.

1999 • 44 citations

Loss of heterozygosity at 13q14 correlates with RB1 gene underexpression in human breast cancer.

2000 • 44 citations

ARF mutation accelerates pituitary tumor development in Rb +/− mice

2002 • 42 citations

Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb

2006 • 41 citations

Expression of Ki-67, cyclin D1 and apoptosis markers correlated with survival in prostate cancer patients treated by radical prostatectomy.

2007 • 40 citations

Retinoblastoma Deficiency Increases Chemosensitivity in Lung Cancer

2007 • 40 citations

Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas

2004 • 39 citations

Retinoblastoma (RB1) gene product expression in breast carcinoma. Correlation with Ki-67 growth fraction and biopathological profile.

1998 • 39 citations

Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents

2004 • 39 citations

Life, Death, and E2F: Linking Proliferation Control and DNA Damage Signaling via E2F1

2004 • 38 citations

Genetic diversity of hepatocellular carcinomas and its potential impact on targeted therapies

2007 • 37 citations

Loss of heterozygosity at 13q14 correlates withRB1 gene underexpression in human breast cancer

2000 • 37 citations

Driving the Cell Cycle to Cancer

2003 • 35 citations

Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells.

2000 • 35 citations

Role of the Retinoblastoma Tumor Suppressor in the Maintenance of Genome Integrity

2006 • 35 citations

Loss of Rb overrides the requirement for ERK activity for cell proliferation

2002 • 35 citations

Retinoblastoma protein expression and radiation response in muscle-invasive bladder cancer

1997 • 35 citations

Gene expression profiling in breast cancer

2006 • 34 citations

IncreasedRB1 abnormalities in human primary prostate cancer following combined androgen blockade

1998 • 33 citations

Mutations of the p16 gene product are rare in prostate cancer

1997 • 32 citations

Cyclin D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast cancer

2003 • 30 citations

RETINOBLASTOMA PROTEIN IN HUMAN BREAST CARCINOMA: IMMUNOHISTOCHEMICAL STUDY USING A NEW MONOCLONAL ANTIBODY EFFECTIVE ON ROUTINELY PROCESSED TISSUES

1996 • 28 citations

Therapeutic options in advanced prostate cancer: Present and future

2007 • 27 citations

Downregulation of the Retinoblastoma Gene Expression in the Progression of Malignant Melanoma

2001 • 26 citations

Retinoblastoma protein expression is an independent predictor of both radiation response and survival in muscle-invasive bladder cancer

2003 • 23 citations

Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain

2000 • 23 citations

Separation of Anti-Proliferation and Anti-Apoptotic Functions of Retinoblastoma Protein through Targeted Mutations of Its A/B Domain

2006 • 22 citations

Simian Virus 40 Large T Antigen and Two Independent T-Antigen Segments Sensitize Cells to Apoptosis following Genotoxic Damage

2002 • 22 citations

Is the Loss of pRb Essential for the Mouse Skin

2006 • 21 citations

Melanocytes in conditional Rb–/– mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro

2005 • 19 citations

p16^INK4A Gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy

2004 • 19 citations

Frequent loss of p16 protein expression and high proliferative activity (Ki-67) in malignant melanoma from black Africans.

2001 • 17 citations

The Differential Staurosporine-Mediated G1 Arrest in Normal versus Tumor Cells Is Dependent on the Retinoblastoma Protein

2006 • 16 citations

Predicting risk of breast cancer recurrence using gene-expression profiling

2006 • 14 citations

Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome.

2007 • 12 citations

Analysis of RB Action in DNA Damage Checkpoint Response

2004 • 9 citations

Controversial relationship between the expression of the RB pathway components and RB protein phosphorylation in human breast cancer.

2007 • 5 citations

Abrogation of the p16-Rb pathway in Korean hepatocellular carcinomas.

2001 • 4 citations