Examination of the pRb-Dependent and pRb-Independent Functions of E7 In Vivo

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

2001 • 592 citations

Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis.

1995 • 529 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

The Physical State of Human Papillomavirus Type 16 DNA in Benign and Malignant Genital Tumours

1985 • 480 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

1998 • 450 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.

2002 • 382 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1987 • 351 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

The retinoblastoma gene family: cousins with overlapping interests

1998 • 337 citations

Inactivation of Interferon Regulatory Factor-1 Tumor Suppressor Protein by HPV E7 Oncoprotein

2000 • 314 citations

Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

2001 • 312 citations

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.

2003 • 298 citations

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene

1996 • 264 citations

Modulation of type M ₂ pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

1999 • 247 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1992 • 233 citations

The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle

2000 • 226 citations

The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.

1996 • 212 citations

Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.

2001 • 197 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1992 • 177 citations

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

1989 • 171 citations

Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human Keratinocytes

2001 • 153 citations

Elevated Wild-Type p53 Protein Levels in Human Epithelial Cell Lines Immortalized by the Human Papillomavirus Type 16 E7 Gene

1994 • 137 citations

Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300

2003 • 135 citations

Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.

1994 • 130 citations

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1988 • 130 citations

HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes.

1994 • 124 citations

Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F

1998 • 122 citations

Centrosome Abnormalities and Genomic Instability by Episomal Expression of Human Papillomavirus Type 16 in Raft Cultures of Human Keratinocytes

2001 • 120 citations

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.

1990 • 117 citations

Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

1998 • 117 citations

ATM is a target for positive regulation by E2F-1

2003 • 117 citations

Interaction of the HPV E7 proteins with the pCAF acetyltransferase

2003 • 115 citations

Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins

2000 • 112 citations

Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells

2002 • 110 citations

Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism

1991 • 108 citations

Human Papillomavirus Type 16 E7 Oncoprotein Can Induce Abnormal Centrosome Duplication through a Mechanism Independent of Inactivation of Retinoblastoma Protein Family Members

2003 • 107 citations

Recapitulation of the Effects of the Human Papillomavirus Type 16 E7 Oncogene on Mouse Epithelium by Somatic Rb Deletion and Detection of pRb-Independent Effects of E7 In Vivo

2003 • 105 citations

Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activity.

1997 • 84 citations

Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation

1996 • 79 citations

Identification of a transforming gene of human papillomavirus type 16

1989 • 72 citations

The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19 ^ARF

1999 • 68 citations

Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP.

1997 • 61 citations

Stabilization and Functional Impairment of the Tumor Suppressor p53 by the Human Papillomavirus Type 16 E7 Oncoprotein

2002 • 60 citations

Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice

1997 • 59 citations

Transformation of rat 3Y1 cells by human papillomavirus type‐18 DNA

1988 • 56 citations

Disruption of Retinoblastoma Protein Family Function by Human Papillomavirus Type 16 E7 Oncoprotein Inhibits Lens Development in Part through E2F-1

1999 • 52 citations

Expression of the HPV E7 Oncoprotein Mimics but Does Not Evoke a p53-Dependent Cellular DNA Damage Response Pathway

1999 • 49 citations

Allosteric Activation of Acid α-Glucosidase by the Human Papillomavirus E7 Protein

2000 • 48 citations

E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner.

2003 • 46 citations

The HPV-16 E7 oncoprotein binds Skip and suppresses its transcriptional activity

2001 • 43 citations

Analysis of the p53-Mediated G 1 Growth Arrest Pathway in Cells Expressing the Human Papillomavirus Type 16 E7 Oncoprotein

1997 • 17 citations