The cyclin D1b splice variant: an old oncogene learns new tricks.

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

2013 • 4,554 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

The development of androgen-independent prostate cancer

2001 • 2,285 citations

Molecular determinants of resistance to antiandrogen therapy

2003 • 2,212 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

The Pezcoller lecture: cancer cell cycles revisited.

2000 • 1,208 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Living with or without cyclins and cyclin-dependent kinases

2004 • 1,047 citations

D-type cyclins

1995 • 978 citations

Specific protection against breast cancers by cyclin D1 ablation

2001 • 930 citations

Molecular Biology of the Androgen Receptor

2002 • 917 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

eIF-4E expression and its role in malignancies and metastases

2004 • 702 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

A history of prostate cancer treatment

2002 • 563 citations

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

2000 • 529 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

The human SWI/SNF subunit Brm is a regulator of alternative splicing

2005 • 458 citations

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

2004 • 458 citations

Linking cyclins to transcriptional control

2002 • 434 citations

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

2003 • 421 citations

Alternate splicing produces a novel cyclin D1 transcript.

1995 • 406 citations

Cyclin D1 in Breast Cancer Pathogenesis

2005 • 395 citations

Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

1997 • 386 citations

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

2000 • 384 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Cyclin D1: polymorphism, aberrant splicing and cancer risk

2006 • 360 citations

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

1999 • 358 citations

17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.

1996 • 344 citations

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability

1998 • 338 citations

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

2006 • 312 citations

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

1998 • 301 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor γ-mediated Adipogenesis through Histone Deacetylase Recruitment

2005 • 266 citations

Androgen receptor as a target in androgen-independent prostate cancer

2002 • 265 citations

An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.

2003 • 242 citations

Cyclin D1 expression is regulated by the retinoblastoma protein.

1994 • 235 citations

Cyclin D1 Splice Variants

2003 • 221 citations

Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone.

2000 • 218 citations

Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements

2001 • 200 citations

p21Cip1 Promotes Cyclin D1 Nuclear Accumulation via Direct Inhibition of Nuclear Export

2002 • 198 citations

Multiple G1 Regulatory Elements Control the Androgen-dependent Proliferation of Prostatic Carcinoma Cells

1998 • 197 citations

Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor γ Expression and Transactivation

2003 • 195 citations

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR

2005 • 184 citations

Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner

2001 • 182 citations

P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

1999 • 177 citations

Endocrine treatment in prostate cancer

2000 • 171 citations

Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism

1998 • 165 citations

Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis

2006 • 161 citations

Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling

2006 • 156 citations

Molecular Determinants of Resistance to Antiandrogen Therapy

2004 • 148 citations

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

2006 • 146 citations

Cyclin D1: Mechanism and Consequence of Androgen Receptor Co-repressor Activity

2002 • 143 citations

Down-Regulation of Cyclin D1 Expression by Prostaglandin A₂ Is Mediated by Enhanced Cyclin D1 mRNA Turnover

2000 • 139 citations

Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells

2005 • 138 citations

Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1

2006 • 138 citations

Location, location, location: The role of cyclin D1 nuclear localization in cancer

2005 • 134 citations

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma

2005 • 133 citations

Coactivator AIB1 links estrogen receptor transcriptional activity and stability

2004 • 132 citations

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation

2006 • 130 citations

Cyclin D1 Represses STAT3 Activation through a Cdk4-independent Mechanism

2001 • 115 citations

Cyclin D1 gene (CCND1) mutations in endometrial cancer

2003 • 115 citations

Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes.

1999 • 114 citations

Hormone therapy for patients with prostate carcinoma

2000 • 107 citations

The Androgen Receptor in Prostate Cancer

1996 • 105 citations

Frequent overexpression of the cyclin D1 oncogene in invasive lobular carcinoma of the breast.

1998 • 101 citations

Cyclin D–cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

2002 • 97 citations

Perturbation of cell cycle regulators in human cancer.

1996 • 96 citations

Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors

2002 • 90 citations

D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain

1998 • 90 citations

Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor α Activity

2005 • 87 citations

Cyclin D1 Represses the Basic Helix-Loop-Helix Transcription Factor, BETA2/NeuroD

2002 • 81 citations

Expression of cyclin A and D proteins in prostate cancer and their relation to clinopathological variables and patient survival.

1999 • 80 citations

Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21 ^WAF1/CIP1 expression and correlates with patient survival

2001 • 78 citations

Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21WAF1/CIP1 expression and correlates with patient survival

2001 • 75 citations

A central domain of cyclin D1 mediates nuclear receptor corepressor activity

2004 • 72 citations

Cyclin D1 (PRAD1) alternative transcript b: full-length cDNA cloning and expression in breast cancers

1997 • 70 citations

Specificity of cyclin D1 for androgen receptor regulation.

2003 • 69 citations

Cyclin D1 Binding to the Androgen Receptor (AR) NH2-Terminal Domain Inhibits Activation Function 2 Association and Reveals Dual Roles for AR Corepression

2004 • 67 citations

Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells

1999 • 64 citations

Regulation of B-Myb activity by cyclin D1

2000 • 61 citations

Immunodetectable cyclin D1is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions

2001 • 56 citations

Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells

2000 • 56 citations

DNA Damage Invokes Mismatch Repair-dependent Cyclin D1 Attenuation and Retinoblastoma Signaling Pathways to Inhibit CDK2

2002 • 55 citations

Inhibition of Smad Antiproliferative Function by CDK Phosphorylation

2004 • 54 citations

Differential expression of cell cycle regulatory molecules and evidence for a “cyclin switch” during progression of prostate cancer

2003 • 48 citations

Nutritional modulation of the cell cycle and breast cancer

2004 • 45 citations

The retinoblastoma protein—from bench to bedside

2005 • 44 citations

Protein Kinase C α Signaling Inhibits Cyclin D1 Translation in Intestinal Epithelial Cells

2006 • 43 citations

Functional domains in cyclin D1: pRb-kinase activity is not essential for transformation

1999 • 43 citations

Association of cyclin D1 expression with factors correlated with tumor progression in human hepatocellular carcinoma

1999 • 41 citations

Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner

2001 • 40 citations

Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells.

2000 • 35 citations

Cyclin D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast cancer

2003 • 30 citations

Antagonist/Agonist Balance of the Nonsteroidal Antiandrogen Bicalutamide (Casodex) in a New Prostate Cancer Model

2000 • 28 citations

Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocation

1999 • 27 citations

Induced expression of human CCND1 alternative transcripts in mouse Cyl‐1 knockout fibroblasts highlights functional differences

2004 • 23 citations

Hormone therapy for patients with prostate carcinoma

2000 • 22 citations

Increased Cyclin D1 Expression in Chronic Pancreatitis

1998 • 19 citations

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.

2004 • 14 citations

Expression of cyclin A and D proteins in prostate cancer and their relation to clinopathological variables and patient survival

1999 • 4 citations

Cyclin D1/PRAD1/BCL‐1 alternative transcript [B] protein product in B‐lymphoid malignancies with t(11;14)(q13;q32) translocation

1999 • 2 citations