Cyclin D1 protein expression and gene polymorphism in colorectal cancer

Cancer Cell Cycles

1996 • 5,379 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Principles of CDK regulation

1995 • 3,267 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1999 • 1,152 citations

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

1995 • 1,117 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

Alternate splicing produces a novel cyclin D1 transcript.

1995 • 406 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

1995 • 339 citations

Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis

1996 • 318 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas.

1994 • 263 citations

Role of the retinoblastoma protein in the pathogenesis of human cancer.

1997 • 256 citations

PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma

1994 • 242 citations

Tumour markers of prognosis in colorectal cancer

1998 • 229 citations

Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer

1996 • 217 citations

Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

1999 • 186 citations

The PRAD‐1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas

1994 • 160 citations

Management and survival of patients with adenocarcinoma of the colon and rectum: a national survey of the Commission on Cancer.

1995 • 126 citations

Alternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner

1998 • 121 citations

Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck.

1998 • 99 citations

Expression of cyclin D1 and retinoblastoma protein in colorectal cancer

1998 • 77 citations

Cyclin D<sub>1</sub> Overexpression and Prognosis in Colorectal Adenocarcinoma

1998 • 72 citations

Expression of cell cycle control proteins in primary colorectal tumors does not always predict expression in lymph node metastases.

2000 • 56 citations

Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry

1998 • 39 citations