ARF Is Not Required for Apoptosis in Rb Mutant Mouse Embryos

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

The ARF/p53 pathway

2000 • 647 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

2000 • 504 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

1997 • 405 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

2001 • 331 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

2001 • 201 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

2001 • 165 citations

Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1

1999 • 141 citations

p19^ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 86 citations

Disruption of Retinoblastoma Protein Family Function by Human Papillomavirus Type 16 E7 Oncoprotein Inhibits Lens Development in Part through E2F-1

1999 • 52 citations

p19ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 4 citations