E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Genome-Wide Location and Function of DNA Binding Proteins

2000 • 1,720 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

The Rb/E2F pathway: expanding roles and emerging paradigms

2000 • 1,125 citations

Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF

2001 • 1,101 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle

2001 • 664 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

2001 • 587 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

2000 • 583 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

2000 • 415 citations

Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae : High-Resolution Mapping of Replication Origins

2001 • 413 citations

Combinatorial Control Required for the Specificity of Yeast MAPK Signaling

1997 • 407 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

Securin Is Required for Chromosomal Stability in Human Cells

2001 • 351 citations

E2f3 is critical for normal cellular proliferation

2000 • 323 citations

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

2001 • 323 citations

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

1999 • 279 citations

pRB plays an essential role in cell cycle arrest induced by DNA damage

1998 • 238 citations

Target Gene Specificity of E2F and Pocket Protein Family Members in Living Cells

2000 • 230 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization

1997 • 195 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

2001 • 163 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

Mechanism of Transcriptional Repression of E2F by the Retinoblastoma Tumor Suppressor Protein

1999 • 128 citations

Proliferation is necessary for both repair and mutation in transgenic mouse cells

2000 • 117 citations

Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2

2001 • 74 citations

Active repression and E2F inhibition by pRB are biochemically distinguishable

2001 • 38 citations