p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

Regression Models and Life-Tables

1972 • 27,145 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Association of p53 mutations with short survival in colorectal cancer

1994 • 357 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer

1993 • 249 citations

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

1992 • 233 citations

Prognostic significance of p53 overexpression in gastric and colorectal carcinoma

1992 • 231 citations

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

1991 • 221 citations

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

1990 • 221 citations

Increased p53 protein content of colorectal tumours correlates with poor survival

1992 • 147 citations

Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis

1992 • 140 citations

p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.

1994 • 136 citations

Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer.

1995 • 115 citations

Overexpression of p53 and long-term survival in colon carcinoma

1994 • 79 citations

Antigen retrieval by microwave irradiation lowers immunohistological detection thresholds

1993 • 79 citations

p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck

1995 • 74 citations

p53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance

1993 • 73 citations

p53 and behaviour of colorectal cancer

1994 • 72 citations

Growth factor-regulated G1 cyclins.

1994 • 68 citations

Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma

1995 • 66 citations

Association of p53 Gene and Protein Alterations with Metastases in Colorectal Cancer

1995 • 57 citations

Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer

1995 • 50 citations

Relationship among p53, stage, and prognosis of large bowel cancer

1994 • 50 citations

p53 Expression, mutation, and allelic deletion in ovarian cancer

1994 • 48 citations

POTENTIAL FALSE‐POSITIVE RESULTS WITH ANTIGEN ENHANCEMENT FOR IMMUNOHISTOCHEMISTRY OF THE p53 GENE PRODUCT IN COLORECTAL NEOPLASMS

1996 • 45 citations

Mutations in the p53 gene are not limited to classic 'hot spots' and are not predictive of p53 protein expression in high‐grade non‐Hodgkin's lymphoma

1995 • 45 citations

Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinoma

1993 • 39 citations

POTENTIAL FALSE-POSITIVE RESULTS WITH ANTIGEN ENHANCEMENT FOR IMMUNOHISTOCHEMISTRY OF THE p53 GENE PRODUCT IN COLORECTAL NEOPLASMS

1996 • 37 citations

Correlation between p53 mutations and antibody staining in breast carcinoma

1993 • 28 citations

Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: prognostic significance

1995 • 21 citations

Molecular biology of breast cancer

1994 • 18 citations