Abrogated Response to Cellular Stress Identifies DCIS Associated with Subsequent Tumor Events and Defines Basal-like Breast Tumors

Molecular portraits of human breast tumours

2000 • 15,445 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Prognostic and predictive factors in breast cancer by immunohistochemical analysis.

1998 • 2,121 citations

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

2003 • 2,104 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

The molecular portraits of breast tumors are conserved across microarray platforms

2006 • 1,320 citations

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

2006 • 1,296 citations

Oncogene-induced senescence as an initial barrier in lymphoma development

2005 • 1,153 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Epidemiology of basal-like breast cancer

2007 • 851 citations

Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.

2002 • 786 citations

Tumor suppression by Ink4a–Arf: progress and puzzles

2003 • 700 citations

Prognostic classification of breast ductal carcinoma-in-situ

1995 • 678 citations

Breast-Conserving Treatment With or Without Radiotherapy in Ductal Carcinoma-In-Situ: Ten-Year Results of European Organisation for Research and Treatment of Cancer Randomized Phase III Trial 10853—A Study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group

2006 • 650 citations

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

2001 • 552 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

1998 • 524 citations

Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17

1999 • 512 citations

Rb function in cell-cycle regulation and apoptosis

2000 • 511 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

2006 • 356 citations

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

1995 • 355 citations

Long-term follow-up of in situ carcinoma of the breast.

1994 • 300 citations

Senescence, apoptosis and therapy — cutting the lifelines of cancer

2003 • 290 citations

Suppressing Cancer: The Importance of Being Senescent

2005 • 252 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

Characteristics Associated With Recurrence Among Women With Ductal Carcinoma In Situ Treated by Lumpectomy

2003 • 237 citations

Ductal carcinoma in situ with basal-like phenotype: a possible precursor to invasive basal-like breast cancer

2006 • 224 citations

Identification of a basal-like subtype of breast ductal carcinoma in situ

2007 • 216 citations

COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ

2004 • 200 citations

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein.

1994 • 185 citations

Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins

2000 • 183 citations

Transformation of Human and Murine Fibroblasts without Viral Oncoproteins

2005 • 173 citations

Chromosomal Alterations in Ductal Carcinomas In Situ and Their In Situ Recurrences

2000 • 166 citations

Classification of ductal carcinoma in situ by gene expression profiling

2006 • 161 citations

Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis

2006 • 161 citations

Overexpression of the p16 Cell Cycle Inhibitor in Breast Cancer is Associated with a More Malignant Phenotype

2001 • 155 citations

Histologically normal human mammary epithelia with silenced p16INK4a overexpress COX-2, promoting a premalignant program

2004 • 152 citations

Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

1997 • 150 citations

Cyclooxygenase-2 Transcription Is Regulated by Human Papillomavirus 16 E6 and E7 Oncoproteins: Evidence of a Corepressor/Coactivator Exchange

2007 • 125 citations

p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells

2006 • 124 citations

INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis.

2000 • 119 citations

p16INK4a Immunoexpression: Surrogate Marker of High-risk HPV and High-grade Cervical Intraepithelial Neoplasia

2006 • 116 citations

Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and histopathological parameters

1998 • 112 citations

The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node

2002 • 109 citations

Histological type and marker expression of the primary tumour compared with its local recurrence after breast-conserving therapy for ductal carcinoma in situ

2001 • 107 citations

Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation

1998 • 98 citations

Analysis of gene expression in ductal carcinoma in situ of the breast.

2002 • 91 citations

Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence

2006 • 89 citations

The Senescent Side of Tumor Suppression

2005 • 77 citations

p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue

2005 • 58 citations

p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells

2006 • 57 citations

Comparison of loss heterozygosity in primary and recurrent ductal carcinoma in situ of the breast.

1998 • 42 citations

Tissue microarray analyses of G1/S-regulatory proteins in ductal carcinoma in situ of the breast indicate that low cyclin D1 is associated with local recurrence

2003 • 42 citations

Alterations of p16-pRb Pathway and Chromosome Locus 9p21–22 in Sporadic Invasive Breast Carcinomas

1998 • 40 citations

p16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy

2001 • 33 citations

Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells

2005 • 32 citations

Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma

2005 • 27 citations

Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast

2004 • 12 citations

p16 expression in sentinel nodes with metastatic breast carcinoma: Evaluation of its role in developing triaging strategies for axillary node dissection and a marker of poor prognosis

2004 • 11 citations