RB-Dependent S-Phase Response to DNA Damage

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Cancer Cell Cycles

1996 • 5,379 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

2000 • 650 citations

MCM Proteins in DNA Replication

1999 • 635 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Differential Phosphorylation of the Retinoblastoma Protein by G1/S Cyclin-dependent Kinases

1997 • 486 citations

Control of pRB phosphorylation

1998 • 389 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

Active Transcriptional Repression by the Rb–E2F Complex Mediates G1 Arrest Triggered by p16INK4a, TGFβ, and Contact Inhibition

1999 • 355 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Differential Regulation of Retinoblastoma Protein Function by Specific Cdk Phosphorylation Sites

1996 • 306 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

1997 • 293 citations

The Retinoblastoma Protein Pathway in Cell Cycle Control and Cancer

1997 • 264 citations

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G ₁ arrest after γ-irradiation

1999 • 259 citations

Specific enzymatic dephosphorylation of the retinoblastoma protein.

1993 • 258 citations

Cyclin A-Associated Kinase Activity Is Rate Limiting for Entrance into S Phase and Is Negatively Regulated in G₁ by p27^Kip1

1995 • 252 citations

DNA Damage and Checkpoint Pathways

1998 • 251 citations

BRG-1 is required for RB-mediated cell cycle arrest

2000 • 245 citations

pRB plays an essential role in cell cycle arrest induced by DNA damage

1998 • 238 citations

The Petinoblastoma Tumor Suppressor Protein

1994 • 215 citations

Inhibition of DNA synthesis by RB: effects on G₁/S transition and S-phase progression

1998 • 209 citations

Functions of the retinoblastoma protein

1999 • 204 citations

Role of the Rb/E2F pathway in cell growth control

1997 • 203 citations

RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.

1993 • 195 citations

DNA damage checkpoints update: getting molecular

1998 • 194 citations

RBP1 Recruits Both Histone Deacetylase-Dependent and -Independent Repression Activities to Retinoblastoma Family Proteins

1999 • 171 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.

1995 • 158 citations

Specific Enzymatic Dephosphorylation of the Retinoblastoma Protein

1993 • 96 citations

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

1996 • 81 citations

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F

1998 • 79 citations

Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest

2000 • 77 citations

Cyclin A Is a Functional Target of Retinoblastoma Tumor Suppressor Protein-mediated Cell Cycle Arrest

1999 • 72 citations

Sensitive detection of DNA modifications induced by cisplatin and carboplatin in vitro and in vivo using a monoclonal antibody.

1991 • 68 citations

Rapid dephosphorylation of p107 following UV irradiation

1999 • 46 citations

Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression.

1993 • 38 citations

S phase damage sensing checkpoints in mammalian cells.

1997 • 34 citations

Rb Inhibits the Intrinsic Kinase Activity of TATA-Binding Protein-Associated Factor TAF_II250

1999 • 31 citations

Unscheduled DNA synthesis in cultured ataxia telangiectasia fibroblast-like cells

1980 • 15 citations