IncreasedRB1 abnormalities in human primary prostate cancer following combined androgen blockade

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mammalian G1 cyclins

1993 • 1,990 citations

LNCaP model of human prostatic carcinoma.

1983 • 1,749 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Isolation of a human prostate carcinoma cell line (DU 145)

1978 • 1,176 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

The p53 Gene in Breast Cancer: Prognostic Value of Complementary DNA Sequencing Versus Immunohistochemistry

1996 • 387 citations

Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.

1990 • 342 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Altered Expression of Retinoblastoma Protein and Known Prognostic Variables in Locally Advanced Bladder Cancer

1992 • 254 citations

Impact of Radical Prostatectomy in the Management of Clinically Localized Disease

1994 • 241 citations

Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma.

1996 • 204 citations

Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.

1991 • 184 citations

Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer

1991 • 158 citations

Activated ras alleles in human carcinoma of the prostate are rare.

1991 • 150 citations

Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis

1994 • 149 citations

Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

1995 • 129 citations

Analysis of Alterations in the Retinoblastoma Gene and Tumor Grade in Bone and Soft-Tissue Sarcomas

1991 • 115 citations

An adjustment to the 1997 estimate for new prostate cancer cases

1997 • 108 citations

Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas

1996 • 84 citations

Characterization of the Products of a Gene Expressed During Androgen-Programmed Cell Death and their Potential use as a Marker of Urogenital Injury

1990 • 73 citations

Transcriptional control by the retinoblastoma protein

1995 • 69 citations

Alterations of the retinoblastoma gene in human prostate adenocarcinoma

1996 • 67 citations

Retinoblastoma protein expression is frequently altered in chronic lymphocytic leukemia.

1994 • 46 citations

Quantitation of NM23 Expression in Human Prostate Tissues

1994 • 24 citations

Nucleotide sequence of canine c-N-ras: Codons 1 to 71

1992 • 21 citations

Expression of retinoblastoma gene (Rb) protein in T12MO prostatic adenocarcinoma

1995 • 17 citations

Canine and bovine ras family expression detected and discriminated by use of polymerase chain reaction.

1989 • 15 citations

NM23 Gene Expression in Human Prostatic Carcinomas and Benign Prostatic Hyperplasias: Altered Expression in Combined Androgen Blockaded Carcinomas

1996 • 13 citations