Melanocytes in conditional Rb–/– mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

2000 • 583 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

Z/AP, a Double Reporter for Cre-Mediated Recombination

1999 • 539 citations

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

2003 • 532 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Differential Phosphorylation of the Retinoblastoma Protein by G1/S Cyclin-dependent Kinases

1997 • 486 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

2000 • 415 citations

The retinoblastoma gene family in differentiation and development

1999 • 409 citations

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

2005 • 391 citations

Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival

2003 • 360 citations

Retinoblastoma protein partners

2001 • 348 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1998 • 322 citations

[51] Gene targeting in embryonic stem cells

1993 • 320 citations

MITOTIC CHROMOSOME CONDENSATION

1996 • 319 citations

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

1998 • 316 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.

1996 • 278 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

Malignant melanoma: modern black plague and genetic black box

1998 • 198 citations

Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes

2002 • 188 citations

Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7

1998 • 186 citations

The Regulation of Normal Melanocyte Proliferation

2000 • 179 citations

p16Ink4a in Melanocyte Senescence and Differentiation

2002 • 174 citations

Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals

1999 • 163 citations

Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis

2004 • 145 citations

Opposing roles of pRB and p107 in adipocyte differentiation

2000 • 145 citations

Second primary tumors in patients with retinoblastoma a review of the literature

1997 • 139 citations

The retinoblastoma gene family is differentially expressed during embryogenesis

1997 • 138 citations

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

2004 • 137 citations

HEC, a Novel Nuclear Protein Rich in Leucine Heptad Repeats Specifically Involved in Mitosis

1997 • 137 citations

p130 and p107 Use a Conserved Domain To Inhibit Cellular Cyclin-Dependent Kinase Activity†

1997 • 114 citations

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block

2001 • 107 citations

DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancer

2004 • 99 citations

Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system

2001 • 88 citations

Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells

2000 • 86 citations

Reversal of Growth Suppression by p107 via Direct Phosphorylation by Cyclin D1/Cyclin-Dependent Kinase 4

2002 • 82 citations

Pathways to Melanoma Development: Lessons from the Mouse

2002 • 72 citations

Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability.

2002 • 70 citations

Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.

2000 • 69 citations

Hec1p, an Evolutionarily Conserved Coiled-Coil Protein, Modulates Chromosome Segregation through Interaction with SMC Proteins

1999 • 63 citations

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130

2003 • 56 citations

Tyrosinase‐Cre mice for tissue‐specific gene ablation in neural crest and neuroepithelial‐derived tissues

2003 • 47 citations

Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival

2003 • 42 citations

Apoptosis Induced by the Nuclear Death Domain Protein p84N5 Is Inhibited by Association with Rb Protein

1999 • 39 citations

Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma

2004 • 38 citations

Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1

1998 • 36 citations

Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130

1998 • 36 citations

Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p

2000 • 30 citations

How the other half lives, the amino‐terminal domain of the retinoblastoma tumor suppressor protein

2003 • 29 citations

Modeling malignant melanoma in mice: pathogenesis and maintenance

1999 • 17 citations