Impact of differential cyclin D1 expression and localisation in prostate cancer

Cancer Statistics, 2006

2006 • 5,351 citations

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

2013 • 4,554 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

The development of androgen-independent prostate cancer

2001 • 2,285 citations

Molecular determinants of resistance to antiandrogen therapy

2003 • 2,212 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1999 • 1,152 citations

Living with or without cyclins and cyclin-dependent kinases

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Minireview: Cyclin D1: Normal and Abnormal Functions

2004 • 939 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays.

1999 • 606 citations

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

2000 • 529 citations

Chemistry and Structural Biology of Androgen Receptor

2005 • 496 citations

Linking cyclins to transcriptional control

2002 • 434 citations

Cyclin D1 in Breast Cancer Pathogenesis

2005 • 395 citations

Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence

2003 • 391 citations

Control of pRB phosphorylation

1998 • 389 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1993 • 367 citations

Akt-regulated pathways in prostate cancer

2005 • 349 citations

Androgens Induce Prostate Cancer Cell Proliferation through Mammalian Target of Rapamycin Activation and Post-transcriptional Increases in Cyclin D Proteins

2006 • 289 citations

Prostate Cancer Cell Cycle Regulators: Response to Androgen Withdrawal and Development of Androgen Independence

1999 • 249 citations

An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.

2003 • 242 citations

PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1

2003 • 218 citations

Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone.

2000 • 218 citations

p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

2004 • 205 citations

Nonapical and Cytoplasmic Expression of Interleukin-8, CXCR1, and CXCR2 Correlates with Cell Proliferation and Microvessel Density in Prostate Cancer

2005 • 204 citations

p21Cip1 Promotes Cyclin D1 Nuclear Accumulation via Direct Inhibition of Nuclear Export

2002 • 198 citations

Multiple G1 Regulatory Elements Control the Androgen-dependent Proliferation of Prostatic Carcinoma Cells

1998 • 197 citations

D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability.

1999 • 187 citations

Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner

2001 • 182 citations

A Dominant-Negative Cyclin D1 Mutant Prevents Nuclear Import of Cyclin-Dependent Kinase 4 (CDK4) and Its Phosphorylation by CDK-Activating Kinase

1997 • 179 citations

Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors

1999 • 179 citations

Androgen Regulation of the Cyclin-Dependent Kinase Inhibitor p21 Gene through an Androgen Response Element in the Proximal Promoter

1999 • 177 citations

The activities of cyclin D1 that drive tumorigenesis

2004 • 149 citations

Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells

2005 • 138 citations

Expression of Androgen Receptor Coregulators in Prostate Cancer

2004 • 136 citations

Prognostic and predictive value of p53 and p21 in breast cancer

1998 • 136 citations

Location, location, location: The role of cyclin D1 nuclear localization in cancer

2005 • 134 citations

Inactivation of the p53 pathway in prostate cancer: impact on tumor progression.

1999 • 133 citations

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation

2006 • 130 citations

Cyclin D1 protein expression and gene polymorphism in colorectal cancer

2000 • 121 citations

Update on the Gleason Grading System for Prostate Cancer

2006 • 121 citations

Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors.

1999 • 121 citations

Expression of cell cycle markers in colorectal carcinoma: Superiority of cyclin A as an indicator of poor prognosis

1999 • 101 citations

Metaplastic Carcinoma of the Breast With Osteocartilaginous Heterologous Elements

1998 • 99 citations

Ubiquitination of Free Cyclin D1 Is Independent of Phosphorylation on Threonine 286

2000 • 92 citations

Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors

2002 • 90 citations

The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma

1997 • 85 citations

Proliferation- and apoptosis-associated factors in advanced prostatic carcinomas before and after androgen deprivation therapy: prognostic significance of p21/WAF1/CIP1 expression

1999 • 85 citations

Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67

2001 • 84 citations

Cyclin D1 expression in human prostate carcinoma cell lines and primary tumors

1998 • 84 citations

Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization

2001 • 82 citations

Expression of cyclin A and D proteins in prostate cancer and their relation to clinopathological variables and patient survival.

1999 • 80 citations

Androgen receptor corepressors and prostate cancer

2006 • 80 citations

Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21 ^WAF1/CIP1 expression and correlates with patient survival

2001 • 78 citations

Expression of cyclin D1 and retinoblastoma protein in colorectal cancer

1998 • 77 citations

Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21WAF1/CIP1 expression and correlates with patient survival

2001 • 75 citations

The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines

2006 • 75 citations

A central domain of cyclin D1 mediates nuclear receptor corepressor activity

2004 • 72 citations

Specificity of cyclin D1 for androgen receptor regulation.

2003 • 69 citations

Cyclin D1 Binding to the Androgen Receptor (AR) NH2-Terminal Domain Inhibits Activation Function 2 Association and Reveals Dual Roles for AR Corepression

2004 • 67 citations

Molecular biology of laryngeal squamous cell carcinoma

2003 • 66 citations

The PSA Era is not Over for Prostate Cancer

2005 • 65 citations

Tumour suppressor genes in prostate cancer

1997 • 65 citations

Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells

1999 • 64 citations

Overexpression of cyclin D1 is rare in human prostate carcinoma

1999 • 59 citations

The association of p21((WAF-1/CIP1)) with progression to androgen-independent prostate cancer.

2002 • 55 citations

Calmodulin and Cyclin D Anchoring Sites on the Src-Suppressed C Kinase Substrate, SSeCKS

2002 • 52 citations

Ras‐induced colony formation and anchorage‐independent growth inhibited by elevated expression of Purα in NIH3T3 cells

2001 • 51 citations

Genesis of pituitary adenomas: state of the art.

2001 • 50 citations

Aberrant expression of G1/S regulators is a frequent event in sporadic pituitary adenomas

2001 • 50 citations

Characterization of t(11;14) translocation in mantle cell lymphoma by fluorescent in situ hybridization.

1996 • 49 citations

A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma

2005 • 46 citations

Immunohistochemical study of p21WAF1 and p53 proteins in prostatic cancer and their prognostic significance

1998 • 42 citations

Association of cyclin D1 expression with factors correlated with tumor progression in human hepatocellular carcinoma

1999 • 41 citations

Relationship of p21WAF1 expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa)

1999 • 40 citations

High Pin1 expression is associated with tumor progression in colorectal cancer

2006 • 38 citations

Differential requirements for ras and the retinoblastoma tumor suppressor protein in the androgen dependence of prostatic adenocarcinoma cells.

2000 • 35 citations

Expression of transforming growth factor-beta-1 and p27Kip1 in pancreatic adenocarcinomas: relation with cell-cycle-associated proteins and clinicopathologic characteristics

2005 • 34 citations

Expression of p21 cell cycle protein is an independent predictor of response to salvage radiotherapy after radical prostatectomy

2003 • 32 citations

Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer

2000 • 31 citations

Hormone refractory prostate cancer: Management and advances

2006 • 29 citations

Relationship of p21^WAF‐I protein expression with prognosis in advanced prostate cancer treated by androgen ablation

2001 • 29 citations

Cytoplasmic sequestration of cyclin D1 associated with cell cycle withdrawal of neuroblastoma cells

2005 • 29 citations

Prognostic value of cyclin D1 overexpression in correlation with pRb and p53 status in non-small cell lung cancer (NSCLC)

2005 • 25 citations

Molecular mechanisms of prostate cancer

2001 • 19 citations

Cyclin D1 Protein Expression in Human Thyroid gland and Thyroid Cancer

2005 • 18 citations

Histopathologic and biologic characteristics of a transitional cell carcinoma with inverted papilloma-like endophytic growth pattern

2003 • 14 citations

Targeted therapies for prostate cancer

2005 • 11 citations

Expression of p21 and mutant p53 gene products in residual prostatic tumor cells after radical radiotherapy

1997 • 11 citations

Welcome from the new Editor-in-Chief

2006 • 8 citations