Context and location dependence of adaptive Foxp3+ regulatory T cell formation during immunopathological conditions

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Regulatory T Cells: Mechanisms of Differentiation and Function

2007 • 2,574 citations

Follicular Helper CD4 T Cells (T_FH)

2011 • 2,505 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

2010 • 1,973 citations

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Peripheral education of the immune system by colonic commensal microbiota

2011 • 961 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

2009 • 528 citations

Induced CD4⁺Foxp3⁺Regulatory T Cells in Immune Tolerance

2012 • 519 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Oral tolerance

2011 • 502 citations

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

2008 • 499 citations

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

2008 • 487 citations

Oral tolerance.

1994 • 456 citations

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

2010 • 450 citations

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

2007 • 434 citations

Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

2008 • 406 citations

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

2011 • 404 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

Oral tolerance: Basic mechanisms and applications of oral tolerance

2011 • 395 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

2010 • 393 citations

Foxo Transcription Factors Control Regulatory T Cell Development and Function

2010 • 391 citations

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

2009 • 353 citations

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

2010 • 352 citations

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

2009 • 324 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells

2003 • 292 citations

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE

2006 • 291 citations

Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

2008 • 265 citations

GATA3-Driven Th2 Responses Inhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells

2007 • 262 citations

Improving T Cell Therapy for Cancer

2006 • 248 citations

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo

2011 • 240 citations

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

2009 • 217 citations

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

2010 • 212 citations

Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells

2009 • 212 citations

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

2010 • 208 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

A Kinetic and Dynamic Analysis of Foxp3 Induced in T Cells by TGF-β

2007 • 198 citations

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

2010 • 197 citations

IL‐27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

2007 • 188 citations

Intestinal inflammation abrogates the tolerogenic properties of MLN CD103⁺ dendritic cells

2010 • 187 citations

Antigen-specific peripheral shaping of the natural regulatory T cell population

2008 • 185 citations

1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region

2012 • 182 citations

Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

2012 • 182 citations

IL-27 inhibits the development of regulatory T cells via STAT3

2007 • 180 citations

Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

2010 • 178 citations

Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-

2006 • 172 citations

FOXP3 and the regulation of Treg/Th17 differentiation

2009 • 168 citations

Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3

2010 • 160 citations

STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor

2008 • 144 citations

ICOS-Dependent Homeostasis and Function of Foxp3+ Regulatory T Cells in Islets of Nonobese Diabetic Mice

2012 • 137 citations

Biological Functions of Regulatory T Cells

2011 • 135 citations

Induction of regulatory T cells by green tea polyphenol EGCG

2011 • 134 citations

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

2011 • 133 citations

TGF‐β‐induced Foxp3⁺ regulatory T cells rescue scurfy mice

2008 • 130 citations

Mitigation of Experimental Allergic Encephalomyelitis by TGF-β Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance

2008 • 116 citations

Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

2010 • 115 citations

All-transRetinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells

2008 • 112 citations

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors

2011 • 110 citations

Progesterone suppresses the m<scp>TOR</scp> pathway and promotes generation of induced regulatory <scp>T</scp> cells with increased stability

2012 • 108 citations

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

2011 • 106 citations

Smad3 Differentially Regulates the Induction of Regulatory and Inflammatory T Cell Differentiation

2009 • 102 citations

Control of homeostatic proliferation by regulatory T cells

2005 • 98 citations

The TCR-mediated signaling pathways that control the direction of helper T cell differentiation

2010 • 98 citations

IFN‐γ‐STAT1 signal regulates the differentiation of inducible Treg: Potential role for ROS‐mediated apoptosis

2009 • 92 citations

High TCR diversity ensures optimal function andhomeostasis of Foxp3⁺ regulatory Tcells

2011 • 92 citations

Molecular mechanisms regulating TGF-β-induced Foxp3 expression

2010 • 91 citations

Role of TGF-β in the Induction of Foxp3 Expression and T Regulatory Cell Function

2008 • 89 citations

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

2011 • 89 citations

Instability of Foxp3 Expression Limits the Ability of Induced Regulatory T Cells to Mitigate Graft versus Host Disease

2011 • 87 citations

Notch1 Signaling and Regulatory T Cell Function

2008 • 87 citations

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

2008 • 83 citations

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

2007 • 81 citations

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

2012 • 79 citations

Programming of Regulatory T Cells from Pluripotent Stem Cells and Prevention of Autoimmunity

2012 • 75 citations

Identification of an immediate Foxp3− precursor to Foxp3+ regulatory T cells in peripheral lymphoid organs of nonmanipulated mice

2010 • 74 citations

The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences

2012 • 72 citations

Peripherally Induced Treg: Mode, Stability, and Role in Specific Tolerance

2008 • 72 citations

TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation

2011 • 71 citations

Regulatory T-cell stability and plasticity in mucosal and systemic immune systems

2010 • 70 citations

Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection

2011 • 69 citations

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

2008 • 66 citations

Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses

2011 • 65 citations

Nature and nurture in Foxp3+ regulatory T cell development, stability, and function

2011 • 60 citations

Induced regulatory T cells: mechanisms of conversion and suppressive potential

2012 • 58 citations

Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD

2012 • 46 citations

Protein Kinase C-θ Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a–Dependent Pathway

2012 • 43 citations

A Novel Clinically Relevant Approach to Tip the Balance Toward Regulation in Stringent Transplant Model

2010 • 42 citations

Expanding and converting regulatory T cells: a horizon for immunotherapy

2009 • 41 citations

Polyclonal Treg cells modulate T effector cell trafficking

2011 • 41 citations

Dendritic Cell-Targeted Pancreatic β-Cell Antigen Leads to Conversion of Self-Reactive CD4⁺T Cells Into Regulatory T Cells and Promotes Immunotolerance in NOD Mice

2010 • 41 citations

Human Tumor Antigen-Specific Helper and Regulatory T Cells Share Common Epitope Specificity but Exhibit Distinct T Cell Repertoire

2010 • 40 citations

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

2011 • 40 citations

SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4+ T Cells into CD4+FoxP3+ T Regulatory Cells by Production of IFN-γ

2012 • 39 citations

An early age‐related increase in the frequency of CD4⁺ Foxp3⁺ cells in BDC2·5NOD mice

2007 • 39 citations

T Cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T Cells

2009 • 38 citations

CD4+CD25+Foxp3+ Regulatory T Cells Optimize Diversity of the Conventional T Cell Repertoire during Reconstitution from Lymphopenia

2010 • 36 citations

Disruption of TGF-β Signaling Prevents the Generation of Tumor-Sensitized Regulatory T Cells and Facilitates Therapeutic Antitumor Immunity

2009 • 35 citations

Constitutive Nuclear Localization of NFAT in Foxp3+ Regulatory T Cells Independent of Calcineurin Activity

2012 • 32 citations

IL4 blockade of inducible regulatory T cell differentiation: The role of Th2 cells, Gata3 and PU.1

2008 • 30 citations

Aryl hydrocarbon receptor controls regulatory CD4+T cell function

2012 • 27 citations

Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls

2010 • 23 citations

Antigen-Specific Induction of Regulatory T Cells In Vivo and In Vitro

2011 • 23 citations

Discrete TCR Repertoires and CDR3 Features Distinguish Effector and Foxp3+ Regulatory T Lymphocytes in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Allergic Encephalomyelitis

2010 • 20 citations

Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice

2011 • 18 citations

Intratumoral Convergence of the TCR Repertoires of Effector and Foxp3+ CD4+ T cells

2010 • 14 citations

Protective Response Against Type 1 Diabetes in Nonobese Diabetic Mice After Coimmunization with Insulin and DNA Encoding Proinsulin

2009 • 11 citations

Efficient induction of CD25- iTreg by co-immunization requires strongly antigenic epitopes for T cells

2011 • 10 citations

T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3

2011 • 9 citations