1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

FOXP3+ regulatory T cells in the human immune system

2010 • 2,283 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Plasticity of CD4+ T Cell Lineage Differentiation

2009 • 1,476 citations

Vitamin effects on the immune system: vitamins A and D take centre stage

2008 • 1,441 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

2006 • 768 citations

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

2009 • 738 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

Vitamin D and autoimmunity: new aetiological and therapeutic considerations

2007 • 697 citations

Vitamin D and diabetes

2005 • 618 citations

Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus

2007 • 600 citations

Immunomodulatory effects of Vitamin D in multiple sclerosis

2009 • 514 citations

1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.

1991 • 475 citations

Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile

2007 • 458 citations

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

2009 • 457 citations

Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3

2005 • 403 citations

Transcriptional Repression of the Interleukin-2 Gene by Vitamin D₃: Direct Inhibition of NFATp/AP-1 Complex Formation by a Nuclear Hormone Receptor

1995 • 399 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

Decreased FOXP3 levels in multiple sclerosis patients

2005 • 367 citations

Compromised CD4⁺ CD25^high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell level

2007 • 339 citations

Transient regulatory T-cells: A state attained by all activated human T-cells

2006 • 336 citations

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

2007 • 302 citations

Vitamin D3: a transcriptional modulator of the interferon-γ gene

1998 • 274 citations

Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes

2007 • 267 citations

Indoleamine 2,3-dioxygenase–expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells

2009 • 248 citations

1,25-Dihydroxyvitamin D ₃ Attenuates of Expression of Experimental Murine Lupus of MRL/1 Mice

1992 • 243 citations

IL-10 Signaling Is Essential for 1,25-Dihydroxyvitamin D3-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis

2006 • 214 citations

Activation of retinoic acid receptor‐α favours regulatory T cell induction at the expense of IL‐17‐secreting T helper cell differentiation

2007 • 195 citations

Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia.

2001 • 184 citations

Reduced Number and Function of CD4+ CD25 high FoxP3 + Regulatory T Cells in Patients with Systemic Lupus Erythematosus

2007 • 163 citations

Vitamin D3 metabolism in patients with rheumatic diseases: Low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus

1995 • 160 citations

CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases

2007 • 154 citations

Prevalence of Vitamin D Insufficiency/Deficiency in Rheumatoid Arthritis and Associations with Disease Severity and Activity

2010 • 146 citations

1,25‐Dihydroxyvitamin D₃ acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis

2011 • 143 citations

Selective use of multiple vitamin D response elements underlies the 1 ,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene

2007 • 103 citations

Relationships among vitamin D, disease activity, pain and disability in rheumatoid arthritis.

2010 • 98 citations

Prevention of immunological disorders in MRL/l mice by a new synthetic analogue of vitamin D3: 22-oxa-1.ALPHA., 25-dihydroxyvitamin D3.

1990 • 96 citations

The Vitamin D Receptor

2007 • 77 citations

1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells

2011 • 69 citations

Reduction of forkhead box P3 levels in CD4+CD25high T cells in patients with new-onset systemic lupus erythematosus

2008 • 68 citations