Nature and nurture in Foxp3+ regulatory T cell development, stability, and function

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

2010 • 3,305 citations

How regulatory T cells work

2008 • 3,048 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

FOXP3+ regulatory T cells in the human immune system

2010 • 2,283 citations

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

2010 • 1,973 citations

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

2009 • 1,887 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

2008 • 1,695 citations

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

2010 • 1,278 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

2010 • 960 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

2009 • 934 citations

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

2009 • 898 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

IL-35-mediated induction of a potent regulatory T cell population

2010 • 791 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Stability of the Regulatory T Cell Lineage in Vivo

2010 • 675 citations

Identification of IL-17-producing FOXP3⁺regulatory T cells in humans

2009 • 657 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

2009 • 563 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

Control of Regulatory T Cell Lineage Commitment and Maintenance

2009 • 557 citations

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

2009 • 528 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

2008 • 510 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

IL-17–producing human peripheral regulatory T cells retain suppressive function

2009 • 471 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

2010 • 443 citations

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

2007 • 434 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Foxo Transcription Factors Control Regulatory T Cell Development and Function

2010 • 391 citations

Epigenetic mechanisms of regulation of Foxp3 expression

2009 • 354 citations

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

2009 • 353 citations

Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression

2002 • 318 citations

Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other

2008 • 317 citations

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

2006 • 316 citations

Plasticity of CD4+ FoxP3+ T cells

2009 • 301 citations

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

2010 • 296 citations

Human memory FOXP3⁺Tregs secrete IL-17 ex vivo and constitutively express the T_H17 lineage-specific transcription factor RORγt

2009 • 293 citations

IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

2005 • 292 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

2010 • 266 citations

Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation

2010 • 265 citations

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

2010 • 261 citations

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking

2005 • 260 citations

Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

2007 • 254 citations

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

2009 • 248 citations

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4

2002 • 244 citations

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions

2009 • 236 citations

Differentiation of regulatory Foxp3⁺T cells in the thymic cortex

2008 • 227 citations

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

2010 • 226 citations

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

2010 • 224 citations

CD4⁺ T‐regulatory cells: toward therapy for human diseases

2008 • 221 citations

Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells

2007 • 215 citations

Bacterial strain‐specific induction of Foxp3⁺ T regulatory cells is protective in murine allergy models

2010 • 214 citations

RUNX proteins in transcription factor networks that regulate T-cell lineage choice

2009 • 212 citations

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

2010 • 208 citations

A Kinetic and Dynamic Analysis of Foxp3 Induced in T Cells by TGF-β

2007 • 198 citations

Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

2010 • 192 citations

Structure-Function Relationship between the Human Chemokine Receptor CXCR3 and Its Ligands

2002 • 185 citations

Antigen-specific peripheral shaping of the natural regulatory T cell population

2008 • 185 citations

FOXP3 and the regulation of Treg/Th17 differentiation

2009 • 168 citations

Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3

2010 • 160 citations

CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

2008 • 160 citations

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells

2007 • 156 citations

Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells

2002 • 150 citations

Adaptive Islet-Specific Regulatory CD4 T Cells Control Autoimmune Diabetes and Mediate the Disappearance of Pathogenic Th1 Cells In Vivo

2006 • 140 citations

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

2009 • 137 citations

IFN Regulatory Factor 4 Regulates the Expression of a Subset of Th2 Cytokines

2009 • 132 citations

CCR6 regulates EAE pathogenesis by controlling regulatory CD4⁺ T‐cell recruitment to target tissues

2009 • 121 citations

Human memory FOXP3+ Treg secrete IL-17 ex-vivo and constitutively express the TH17 lineage specific transcription factor ROR{gamma}t

2009 • 117 citations

Mitigation of Experimental Allergic Encephalomyelitis by TGF-β Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance

2008 • 116 citations

Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

2010 • 115 citations

Early events in the thymus affect the balance of effector and regulatory T cells

2006 • 98 citations

Regulatory T cells: roles of T cell receptor for their development and function

2010 • 92 citations

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

2011 • 89 citations

The T‐cell receptor repertoire of regulatory T cells

2008 • 88 citations

IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4 ⁺ CD25 ⁺ T lymphocytes

2005 • 88 citations

CCR6 Marks Regulatory T Cells as a Colon-Tropic, IL-10–Producing Phenotype

2010 • 84 citations

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

2008 • 83 citations

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

2007 • 81 citations

Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient

2006 • 79 citations

Regulation of the foxp3 Gene by the Th1 Cytokines: The Role of IL-27-Induced STAT1

2009 • 79 citations

CD28 Facilitates the Generation of Foxp3− Cytokine Responsive Regulatory T Cell Precursors

2010 • 72 citations

CD4-CD8 Lineage Differentiation: Thpok-ing into the Nucleus

2009 • 72 citations

Regulatory function ofin vivoanergized CD4⁺T cells

2001 • 63 citations

Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function

2011 • 59 citations

Rare Development of Foxp3+ Thymocytes in the CD4+CD8+ Subset

2009 • 59 citations

Cutting Edge: Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity

2009 • 56 citations

Myelin-Reactive, TGF-β–Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo

2010 • 54 citations

CD4+CD25+ Regulatory T Cell Repertoire Formation Shaped by Differential Presentation of Peptides from a Self-Antigen

2008 • 51 citations

Sub‐optimal CD4⁺ T‐cell activation triggers autonomous TGF‐β‐dependent conversion to Foxp3⁺ regulatory T cells

2011 • 46 citations

Shaping of the Autoreactive Regulatory T Cell Repertoire by Thymic Cortical Positive Selection

2007 • 42 citations

CD4⁺ T‐cell development in a mouse expressing a transgenic TCR derived from a Treg

2008 • 41 citations

Human Tumor Antigen-Specific Helper and Regulatory T Cells Share Common Epitope Specificity but Exhibit Distinct T Cell Repertoire

2010 • 40 citations

T Cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T Cells

2009 • 38 citations

How specificity for self-peptides shapes the development and function of regulatory T cells

2010 • 38 citations

Rethinking the molecular definition of regulatory T cells

2008 • 36 citations

Retrogenic Modeling of Experimental Allergic Encephalomyelitis Associates T Cell Frequency but Not TCR Functional Affinity with Pathogenicity

2008 • 33 citations

Antigen Nonspecific Suppression of T Cell Responses by Activated Stimulation-Refractory CD4+ T Cells

2004 • 27 citations

Antigen-Specific Induction of Regulatory T Cells In Vivo and In Vitro

2011 • 23 citations

Discrete TCR Repertoires and CDR3 Features Distinguish Effector and Foxp3+ Regulatory T Lymphocytes in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Allergic Encephalomyelitis

2010 • 20 citations

Defective cell cycle induction by IL-2 in naive T-cells antigen stimulated in the presence of refractory T-lymphocytes

2006 • 20 citations

Intratumoral Convergence of the TCR Repertoires of Effector and Foxp3+ CD4+ T cells

2010 • 14 citations

Thymic Selection and Lineage Commitment of CD4+Foxp3+ Regulatory T Lymphocytes

2010 • 13 citations

In Vivo Suppression of Naive CD4 T Cell Responses by IL-2- and Antigen-Stimulated T Lymphocytes in the Absence of APC Competition

2008 • 3 citations