Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

TRANSFAC(R) and its module TRANSCompel(R): transcriptional gene regulation in eukaryotes

2005 • 2,172 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

MATCHTM: a tool for searching transcription factor binding sites in DNA sequences

2003 • 1,093 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

2017 • 986 citations

Deacetylase inhibition promotes the generation and function of regulatory T cells

2007 • 864 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

DNA methylation controls Foxp3 gene expression

2008 • 729 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3⁺ conventional T cells

2007 • 658 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

2009 • 528 citations

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

2008 • 501 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

2009 • 411 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

2008 • 373 citations

Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

2009 • 363 citations

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

2009 • 353 citations

Loss of FOXP3 expression in natural human CD4⁺CD25⁺ regulatory T cells upon repetitive in vitro stimulation

2009 • 332 citations

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

2009 • 307 citations

Regulatory T cells and treatment of cancer

2008 • 253 citations

Functional Analysis of Promoter CPG-Methylation using a CpG-Free Luciferase Reporter Vector

2006 • 250 citations

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

2009 • 235 citations

Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells

2009 • 212 citations

Ets-1 is a negative regulator of Th17 differentiation

2007 • 199 citations

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

2009 • 189 citations

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells

2009 • 186 citations

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

2008 • 166 citations

Cutting Edge: TCR Stimulation Is Sufficient for Induction of Foxp3 Expression in the Absence of DNA Methyltransferase 1

2009 • 153 citations

CpG methylation has differential effects on the binding of YY1 and ETS proteins to the bi-directional promoter of the Surf-1 and Surf-2 genes

1995 • 97 citations

Activation of the Early B-Cell-Specific mb-1 (Ig-α) Gene by Pax-5 Is Dependent on an Unmethylated Ets Binding Site

2003 • 92 citations

Runx proteins regulate Foxp3 expression

2009 • 86 citations

Self-Limitation of Th1-Mediated Inflammation by IFN-γ

2006 • 86 citations

Ets-1 and Runx2 Regulate Transcription of a Metastatic Gene, Osteopontin, in Murine Colorectal Cancer Cells

2006 • 78 citations

Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells

2008 • 75 citations

Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice

2009 • 68 citations

EAPII interacts with ETS1 and modulates its transcriptional function

2003 • 64 citations

Effects of Histone Deacetylase Inhibitor SAHA on Effector and FOXP3+Regulatory T Cells in Rhesus Macaques

2008 • 33 citations