Control of homeostatic proliferation by regulatory T cells

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

2017 • 986 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

T CELL MEMORY

1998 • 863 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 312 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

Interleukin-7: master regulator of peripheral T-cell homeostasis?

2001 • 290 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

An integrated view of suppressor T cell subsets in immunoregulation

2004 • 248 citations

CD4+ regulatory T cells in autoimmunity and allergy

2002 • 236 citations

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis

2004 • 235 citations

Development and function of CD25+CD4+ regulatory T cells

2004 • 220 citations

Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease

2004 • 208 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

Sensory Adaptation in Naive Peripheral CD4 T Cells

2001 • 163 citations

TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells

2002 • 160 citations

CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice

1998 • 159 citations

Cd4+ T Cell Division in Irradiated Mice Requires Peptides Distinct from Those Responsible for Thymic Selection

1999 • 157 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

Spontaneous proliferation, a response of naïve CD4 T cells determined by the diversity of the memory cell repertoire

2004 • 154 citations

Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

1999 • 146 citations

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

2001 • 139 citations

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors

2001 • 133 citations

A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation

2001 • 130 citations

Homeostatic Expansion Occurs Independently of Costimulatory Signals

2001 • 124 citations

Cutting Edge: Homeostatic Proliferation of Peripheral T Lymphocytes Is Regulated by Clonal Competition

2003 • 123 citations

TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells

2002 • 121 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

Long-Term Survival But Impaired Homeostatic Proliferation of Naïve T Cells in the Absence of p56 ^lck

2000 • 120 citations

Concomitant regulation of T-cell activation and homeostasis

2004 • 111 citations

Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu

1999 • 105 citations

Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪

2001 • 104 citations

Cutting Edge: IL-7-Dependent Homeostatic Proliferation of CD8+ T Cells in Neonatal Mice Allows the Generation of Long-Lived Natural Memory T Cells

2004 • 102 citations

Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis

2000 • 97 citations

Homeostatic T cell proliferation in a T cell-dendritic cell coculture system

2002 • 80 citations

Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

2003 • 76 citations

Regulation of naïve and memory T-cell homeostasis

2002 • 75 citations

Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8 ⁺ T cells expressing the same or different T cell receptors

2004 • 69 citations

Naive CD4+ lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients

2001 • 67 citations

Antiviral CD4 and CD8 T–cell memory: differences in the size of the response and activation requirements

2000 • 64 citations

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

1991 • 63 citations

Homeostatic Competition Among T Cells Revealed by Conditional Inactivation of the Mouse Cd4 Gene

2001 • 59 citations

Type 1 T Regulatory Cells and Their Relationship with CD4 ⁺ CD25 ⁺ T Regulatory Cells

2003 • 49 citations

Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery

2000 • 49 citations

Autoimmune Gastritis: Historical Antecedents, Outstanding Discoveries, and Unresolved Problems

2005 • 40 citations

Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR

1999 • 39 citations

An integrated view of suppressor T cell subsets in immunoregulation

2004 • 39 citations

Genetic isolation of iddm 1 on Chromosome 4 in the BioBreeding (BB) rat

1998 • 34 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 28 citations

Do Regulatory T Cells Play a Role in the Control of Homeostatic Proliferation?

2005 • 11 citations