Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

HES and HERP families: Multiple effectors of the notch signaling pathway

2003 • 1,207 citations

Notch1 functions as a tumor suppressor in mouse skin

2003 • 957 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells

2004 • 890 citations

Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

2004 • 710 citations

The Role of Notch in Promoting Glial and Neural Stem Cell Fates

2002 • 590 citations

Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling

1999 • 568 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

2000 • 411 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression

2000 • 383 citations

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

2003 • 360 citations

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

2003 • 313 citations

Delta1-Notch3 Interactions Bias the Functional Differentiation of Activated CD4+ T Cells

2003 • 289 citations

Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3

2004 • 265 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3

2004 • 230 citations

TCR-Mediated Notch Signaling Regulates Proliferation and IFN-γ Production in Peripheral T Cells

2003 • 228 citations

Coordinated Activation of Notch, Wnt, and Transforming Growth Factor-β Signaling Pathways in Bone Morphogenic Protein 2-induced Osteogenesis

2004 • 225 citations

Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells

2000 • 207 citations

A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

2003 • 198 citations

Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

2003 • 163 citations

Notch 1 Signaling Regulates Peripheral T Cell Activation

2004 • 159 citations

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

2000 • 158 citations

Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

2003 • 157 citations

Transforming Growth Factor-β Induces Renal Epithelial Jagged-1 Expression in Fibrotic Disease

2002 • 144 citations

Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes

2003 • 124 citations

Novel in vitro model for high-rate IgA class switching.

1995 • 121 citations

Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct

2004 • 108 citations

Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.

1999 • 107 citations

REGULATION OF T CELL FATE BY NOTCH

1999 • 105 citations

Notch signaling in lymphopoiesis

2003 • 99 citations

Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation.

1992 • 86 citations

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

2004 • 78 citations

Differential regulation of IgA production by TGF-β and IL-5: TGF-β induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells

1992 • 74 citations

Regulation of Notch signaling genes during BMP2-induced differentiation of osteoblast precursor cells

2004 • 73 citations

Identification and Characterization of Presenilin-independent Notch Signaling

2002 • 52 citations

Notch1 can contribute to viral-induced transformation of primary human keratinocytes.

2003 • 46 citations

Policing the Immune System

2004 • 12 citations