Protein Kinase C-θ Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a–Dependent Pathway

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 • 1,172 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

2011 • 1,023 citations

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

2011 • 971 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

Oral tolerance in the absence of naturally occurring Tregs

2005 • 474 citations

Identification of a Conserved Motif Required for mTOR Signaling

2002 • 472 citations

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

2010 • 470 citations

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

2010 • 443 citations

Foxo Transcription Factors Control Regulatory T Cell Development and Function

2010 • 391 citations

Regulation of the p70 S6 Kinase by Phosphorylation in Vivo

1998 • 375 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

2010 • 296 citations

Protein Kinase C-θ Mediates Negative Feedback on Regulatory T Cell Function

2010 • 278 citations

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

2010 • 261 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo

2011 • 240 citations

Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation

2004 • 228 citations

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

2006 • 227 citations

SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

2004 • 223 citations

Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses

2004 • 202 citations

Protein kinase C theta (PKCθ): A key player in T cell life and death

2007 • 183 citations

Protein kinase Cθ: a new essential superstar on the T-cell stage

2000 • 144 citations

CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

2002 • 142 citations

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

2010 • 136 citations

Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase Cθ-Deficient Mice

2006 • 132 citations

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

2008 • 129 citations

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

2011 • 127 citations

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

2009 • 121 citations

Differential Regulation of Th2 and Th1 Lung Inflammatory Responses by Protein Kinase Cθ

2004 • 120 citations

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells

2008 • 116 citations

The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

2004 • 113 citations

Protein kinase C-α overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal

1999 • 105 citations

FoxO

2004 • 104 citations

PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells

2009 • 103 citations

Protein Kinase Cθ Controls Th1 Cells in Experimental Autoimmune Encephalomyelitis

2005 • 102 citations

Protein Kinase Cϵ Activates Protein Kinase B/Akt via DNA-PK to Protect against Tumor Necrosis Factor-α-induced Cell Death

2006 • 93 citations

PKC-η mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

2004 • 92 citations

T-Cell Receptor-Induced NF-κB Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b

2008 • 91 citations

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

2011 • 89 citations

High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF-κB–Dependent Manner

2011 • 87 citations

T‐cell antigen receptor signal transduction

2002 • 86 citations

c-Rel is crucial for the induction of Foxp3⁺regulatory CD4⁺T cells but not T_H17 cells

2010 • 81 citations

Complex Formation and Cooperation of Protein Kinase Cθ and Akt1/Protein Kinase Bα in the NF-κB Transactivation Cascade in Jurkat T Cells

2001 • 77 citations

Selective function of PKC-theta in T cells.

2006 • 70 citations

Positive feedback regulation of PLCγ1/Ca²⁺ signaling by PKCθ in restimulated T cells via a Tec kinase‐dependent pathway

2004 • 66 citations

Protein Kinase C-θ-Mediated Signals Enhance CD4+ T Cell Survival by Up-Regulating Bcl-xL

2006 • 66 citations

Retinoid-related orphan receptor γt is a potential therapeutic target for controlling inflammatory autoimmunity

2007 • 59 citations

Protein kinase C (PKC)-δ/-ε mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin

2006 • 57 citations

Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase Cβ

2006 • 53 citations

Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells

2005 • 52 citations

The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis

2007 • 37 citations

A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection

2008 • 32 citations

TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha

2010 • 30 citations

Critical role for classical PKC in activating Akt by phospholipase A₂-modified LDL in monocytic cells

2006 • 23 citations

Requirement of Calcineurin Aβ for the Survival of Naive T Cells

2008 • 23 citations

Selective Function of PKC-θ in T cells

2006 • 14 citations

Comment on "PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation"

2006 • 13 citations