Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

2003 • 368 citations

Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

2009 • 363 citations

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

2009 • 353 citations

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

2004 • 297 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

2010 • 266 citations

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

2009 • 235 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

2009 • 215 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

The role of the transcription factor Foxp3 in the development of regulatory T cells

2006 • 181 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells

2008 • 116 citations

Cutting Edge: CD28 and c-Rel–Dependent Pathways Initiate Regulatory T Cell Development

2010 • 110 citations

T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease

2009 • 108 citations

Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo

2001 • 97 citations

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

2009 • 79 citations

CD28 ligation induces transplantation tolerance by IFN-γ–dependent depletion of T cells that recognize alloantigens

2004 • 68 citations

A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant

2006 • 61 citations

β2 integrins separate graft-versus-host disease and graft-versus-leukemia effects

2007 • 48 citations

CD28 Signal Enhances Apoptosis of CD8 T Cells After Strong TCR Ligation

2003 • 38 citations

Paradoxical Functions of B7: CD28 Costimulation in a MHC Class II-Mismatched Cardiac Transplant Model

2009 • 26 citations