Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

2001 • 3,036 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

2010 • 1,278 citations

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

2003 • 1,267 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

2011 • 1,039 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

2007 • 760 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Graft-versus-host disease

2007 • 692 citations

Control of Regulatory T Cell Lineage Commitment and Maintenance

2009 • 557 citations

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

2008 • 520 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia

2003 • 501 citations

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

2009 • 493 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

Molecules and mechanisms of the graft-versus-leukaemia effect

2004 • 379 citations

CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

2007 • 348 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia

2010 • 294 citations

Conditional inactivation of the TGF‐β type II receptor using Cre:Lox

2002 • 265 citations

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo

2011 • 240 citations

CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome

2004 • 237 citations

Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD4+25+ T cells to allow an effective graft-versus-leukemia response

2003 • 199 citations

Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells

2007 • 161 citations

Thymic development and peripheral homeostasis of regulatory T cells

2007 • 160 citations

Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells

2011 • 150 citations

Alloantigen‐specific de novo‐induced Foxp3⁺ Treg revert in vivo and do not protect from experimental GVHD

2009 • 136 citations

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

2009 • 136 citations

Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment

2009 • 112 citations

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment.

1990 • 98 citations

Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity

2005 • 98 citations

Antigen‐dependent suppression of alloresponses by Foxp3‐induced regulatory T cells in transplantation

2005 • 90 citations

Expansion of FOXP3+ CD8 T Cells with Suppressive Potential in Colorectal Mucosa Following a Pathogenic Simian Immunodeficiency Virus Infection Correlates with Diminished Antiviral T Cell Response and Viral Control

2010 • 78 citations

Parallel Expansion of Human Virus-Specific FoxP3− Effector Memory and De Novo-Generated FoxP3+ Regulatory CD8+ T Cells upon Antigen Recognition In Vitro

2007 • 74 citations

IL-6 positively regulates Foxp3+CD8+ T cells in vivo

2009 • 61 citations

FoxP3⁺CD25⁺CD8⁺T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4⁺T-Cell Activation and High Viral Load

2007 • 57 citations

CD8+ suppressor T cells resurrected

2008 • 52 citations

The role of CD8⁺CD28⁻regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand

2007 • 52 citations

A glucocorticoid amplifies IL-2-induced selective expansion of CD4<sup>+</sup>CD25<sup>+</sup>FOXP3<sup>+</sup> regulatory T cells <italic>in vivo</italic> and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation

2009 • 22 citations

Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-β suppress autoimmune diabetes

2010 • 18 citations

Host CD25+CD4+Foxp3+ Regulatory T Cells Primed by anti-CD137 mAbs Inhibit Graft-versus-Host Disease

2011 • 17 citations