Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Non-Smad pathways in TGF-β signaling

2008 • 1,600 citations

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

2006 • 1,520 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Deacetylase inhibition promotes the generation and function of regulatory T cells

2007 • 864 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

Transgenic mice with hematopoietic and lymphoid specific expression of Cre

2003 • 713 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner

2007 • 622 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease

2007 • 556 citations

Active induction of experimental allergic encephalomyelitis

2006 • 527 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

2008 • 499 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling

2007 • 397 citations

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1998 • 368 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

2008 • 349 citations

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

2008 • 347 citations

Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other

2008 • 317 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome

2004 • 237 citations

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells

2007 • 220 citations

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads

2008 • 181 citations

CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases

2007 • 154 citations

ERK1−/− Mice Exhibit Th1 Cell Polarization and Increased Susceptibility to Experimental Autoimmune Encephalomyelitis

2006 • 148 citations

Prevention of the Onset and Progression of Collagen-Induced Arthritis in Rats by the Potent p38 Mitogen-Activated Protein Kinase Inhibitor FR167653

2005 • 148 citations

Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation

2004 • 137 citations

Synergistic effect of TGF‐β superfamily members on the induction of Foxp3⁺ Treg

2009 • 100 citations

TGF- receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung

2008 • 80 citations

TGF-β1 inhibition of IFN-γ-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent

2007 • 51 citations

Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

2006 • 48 citations

The role of NF‐κB and Smad3 in TGF‐β‐mediated Foxp3 expression

2009 • 48 citations

Transforming growth factor-/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity

2008 • 41 citations