IL‐27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

2007 • 1,418 citations

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

2002 • 1,401 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Immunity, Inflammation, and Allergy in the Gut

2005 • 1,036 citations

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

2006 • 947 citations

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

2006 • 831 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

2003 • 534 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

IL-27 regulates IL-12 responsiveness of naïve CD4 ⁺ T cells through Stat1-dependent and -independent mechanisms

2003 • 456 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

2000 • 394 citations

The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis

2005 • 285 citations

Transforming growth factor induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis

2005 • 237 citations

Understanding the Pro- and Anti-Inflammatory Properties of IL-27

2004 • 227 citations

IL-27 Limits IL-2 Production during Th1 Differentiation

2006 • 213 citations

Regulatory T cells in the periphery

2006 • 189 citations

Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice

2002 • 176 citations

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27

2006 • 176 citations

EBV-Induced Gene 3 Transcription Is Induced by TLR Signaling in Primary Dendritic Cells via NF-κB Activation

2005 • 152 citations

IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3

2006 • 133 citations

Impaired Development of CD4+ CD25+ Regulatory T Cells in the Absence of STAT1

2003 • 131 citations

Suppression of Ongoing Experimental Autoimmune Encephalomyelitis by Neutralizing the Function of the p28 Subunit of IL-27

2004 • 69 citations