Intratumoral Convergence of the TCR Repertoires of Effector and Foxp3+ CD4+ T cells

On Information and Sufficiency

1951 • 17,995 citations

Cancer-related inflammation

2008 • 10,288 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Nonparametric estimation of the number of classes in a population

1984 • 4,120 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

2006 • 3,040 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion

2007 • 910 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

2010 • 796 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

2008 • 503 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

2003 • 474 citations

Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells

2008 • 452 citations

Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β

2007 • 438 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans

2004 • 415 citations

Epitope Landscape in Breast and Colorectal Cancer

2008 • 408 citations

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

2008 • 360 citations

Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other

2008 • 317 citations

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

2006 • 316 citations

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

2005 • 275 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets

2010 • 258 citations

Regulatory T cells and treatment of cancer

2008 • 253 citations

Tumor-Induced Expansion of Regulatory T Cells by Conversion of CD4+CD25− Lymphocytes Is Thymus and Proliferation Independent

2006 • 252 citations

CD4⁺ T‐regulatory cells: toward therapy for human diseases

2008 • 221 citations

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

2009 • 217 citations

Cross-presentation of tumor antigens by bone marrow–derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression

2001 • 214 citations

Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance

2007 • 213 citations

Clonal Selection of Helper T Cells Is Determined by an Affinity Threshold with No Further Skewing of TCR Binding Properties

2004 • 171 citations

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

2005 • 169 citations

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

2008 • 153 citations

Immunotherapy of human cancer: lessons from mice

2000 • 143 citations

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

2008 • 140 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice

2009 • 127 citations

In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions

2000 • 81 citations

Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity

2001 • 69 citations

Cell surface expression of class II MHC proteins bound by a single peptide.

1995 • 63 citations

Identification and characterization of T helper epitopes in the nucleoprotein of influenza A virus.

1989 • 62 citations

Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

2006 • 51 citations

The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy

2008 • 42 citations

Tumor Recognition and Self-Recognition Induce Distinct Transcriptional Profiles in Antigen-Specific CD4 T Cells

2009 • 36 citations

TCR Repertoire and Foxp3 Expression Define Functionally Distinct Subsets of CD4+ Regulatory T Cells

2009 • 30 citations

Antigen‐independent accumulation of activated effector/memory T lymphocytes into human and murine tumors

2005 • 29 citations

In the Normal Repertoire of CD4+ T Cells, a Single Class II MHC/Peptide Complex Positively Selects TCRs with Various Antigen Specificities

1999 • 24 citations

αβTCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand

2001 • 19 citations

Presentation of antagonist peptides to naive CD4 ⁺ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells

2002 • 11 citations

CD4+ T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head and neck cancer

2009 • 10 citations