Calcium signaling in the development and function of T‐lineage cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Molecular Physiology of P2X Receptors

2002 • 2,845 citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx

2005 • 2,020 citations

Transcriptional regulation by calcium, calcineurin, and NFAT

2003 • 1,893 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

STIM1, an essential and conserved component of store-operated Ca2+ channel function

2005 • 1,757 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

AN INTRODUCTION TO TRP CHANNELS

2005 • 1,512 citations

NFAT proteins: key regulators of T-cell development and function

2005 • 1,434 citations

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

2005 • 1,358 citations

Orai1 is an essential pore subunit of the CRAC channel

2006 • 1,305 citations

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

2006 • 1,285 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Calcium signalling in lymphocyte activation and disease

2007 • 990 citations

Altered Cytokine Production in Mice Lacking P2X7Receptors

2001 • 918 citations

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

2009 • 897 citations

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

2001 • 877 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

Genome-wide RNAi screen of Ca ²⁺ influx identifies genes that regulate Ca ²⁺ release-activated Ca ²⁺ channel activity

2006 • 838 citations

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

2003 • 822 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 • 797 citations

LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death

2002 • 794 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

2006 • 772 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

The unconventional lifestyle of NKT cells

2002 • 756 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

2007 • 649 citations

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

2009 • 644 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

2006 • 630 citations

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

2003 • 598 citations

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca ²⁺ store depletion

2007 • 592 citations

The transcription factor NF-ATc is essential for cardiac valve formation

1998 • 580 citations

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

2008 • 573 citations

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

2006 • 571 citations

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

2008 • 569 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Control of Regulatory T Cell Lineage Commitment and Maintenance

2009 • 557 citations

CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

2006 • 555 citations

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

2008 • 538 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

The molecular choreography of a store-operated calcium channel

2007 • 502 citations

STIM1Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity

2009 • 481 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity

2000 • 453 citations

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

2008 • 433 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

2003 • 400 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

Calcium signaling in lymphocytes

2008 • 394 citations

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels

2007 • 388 citations

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

2006 • 383 citations

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

2008 • 380 citations

Biochemical and Functional Characterization of Orai Proteins

2007 • 375 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

Integration of calcium and RAS signalling

2002 • 375 citations

CRACM1, CRACM2, and CRACM3 Are Store-Operated Ca2+ Channels with Distinct Functional Properties

2007 • 369 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses

2007 • 331 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

2009 • 312 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 294 citations

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

2008 • 288 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

ORAI1 and STIM1 deficiency in human and mice: roles of store‐operated Ca²⁺ entry in the immune system and beyond

2009 • 279 citations

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells

1998 • 271 citations

Autocrine regulation of T‐cell activation by ATP release and P2X₇receptors

2009 • 271 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation

2008 • 255 citations

Functional stoichiometry of the unitary calcium-release-activated calcium channel

2008 • 249 citations

Calcium Inhibition and Calcium Potentiation of Orai1, Orai2, and Orai3 Calcium Release-activated Calcium Channels

2007 • 236 citations

Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment

2005 • 235 citations

Regulatory T Cells and T Cell Depletion

2007 • 229 citations

Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1

2006 • 225 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 221 citations

Calcium signalling and cell-fate choice in B cells

2007 • 219 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

2001 • 189 citations

Identification of stromal cell products that interact with pre-B cells.

1996 • 188 citations

Defective T cell development and function incalcineurinAβ-deficient mice

2002 • 182 citations

A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1

2004 • 178 citations

Down-Regulation of IL-4 Gene Transcription and Control of Th2 Cell Differentiation by a Mechanism Involving NFAT1

1997 • 176 citations

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

1995 • 174 citations

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

2008 • 171 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Alternative Polyadenylation Events Contribute to the Induction of NF-ATc in Effector T Cells

1999 • 160 citations

The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells

2009 • 160 citations

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

2008 • 144 citations

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

2005 • 142 citations

Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions

2007 • 138 citations

TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes

2003 • 129 citations

Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings

1996 • 127 citations

Regulation of the Murine Nfatc1 Gene by NFATc2

2002 • 124 citations

LAT-mediated signaling in CD4+CD25+ regulatory T cell development

2005 • 121 citations

Dissecting ICRAC, a store-operated calcium current

2007 • 113 citations

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

2002 • 112 citations

Thymus and autoimmunity. Transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice.

1988 • 111 citations

A Scaffold Protein, AHNAK1, Is Required for Calcium Signaling during T Cell Activation

2008 • 106 citations

Critical role for the β regulatory subunits of Cav channels in T lymphocyte function

2006 • 99 citations

TRPM channels, calcium and redox sensors during innate immune responses

2006 • 89 citations

Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

2005 • 81 citations

Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products

2002 • 81 citations

Stat6-Dependent and -Independent Pathways for IL-4 Production

1999 • 80 citations

STIM1-Independent T Cell Development and Effector Function In Vivo

2009 • 76 citations

Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

2007 • 65 citations

Regulation of Th2 Cytokine Expression in NKT Cells: Unconventional Use of Stat6, GATA-3, and NFAT2

2006 • 61 citations

Selective Role of NFATc3 in Positive Selection of Thymocytes

2007 • 46 citations

Animal models of arthritis caused by systemic alteration of the immune system

2005 • 42 citations

Distinct NFAT Family Proteins Are Involved in the Nuclear NFAT-DNA Binding Complexes from Human Thymocyte Subsets

1998 • 42 citations

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1

2006 • 38 citations

A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation

2007 • 38 citations

Role of NFATx (NFAT4/NFATc3) in Expression of Immunoregulatory Genes in Murine Peripheral CD4+ T Cells

2003 • 32 citations

Early Growth Response 1 and NF-ATc1 Act in Concert to Promote Thymocyte Development beyond the β-Selection Checkpoint

2007 • 26 citations

Structurally delineating stromal interaction molecules as the endoplasmic reticulum calcium sensors and regulators of calcium release‐activated calcium entry

2009 • 22 citations

Selective role of calcineurin in haematopoiesis and lymphopoiesis

2008 • 22 citations