Distinct NFAT Family Proteins Are Involved in the Nuclear NFAT-DNA Binding Complexes from Human Thymocyte Subsets

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Control points in early T-cell development

1993 • 429 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Development of human T and natural killer cells

1995 • 379 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Recombinant NFAT1 (NFATp) Is Regulated by Calcineurin in T Cells and Mediates Transcription of Several Cytokine Genes

1996 • 192 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity

1995 • 168 citations

Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.

1993 • 147 citations

A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region

1995 • 146 citations

The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.

1994 • 134 citations

Human Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Function Is Associated with Cooperative Interactions between AP-1 and NFATp/c

1995 • 133 citations

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT.

1993 • 131 citations

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter

1995 • 100 citations

Mechanisms of transactivation by nuclear factor of activated T cells-1.

1996 • 100 citations

A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation.

1995 • 99 citations

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1995 • 97 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

Characterization of a New Isoform of the NFAT (Nuclear Factor of Activated T Cells) Gene Family Member NFATc

1996 • 86 citations

The Human gp39 Promoter

1995 • 86 citations

Quantitative PCR: validation of the use of a multispecific internal control

1994 • 79 citations

Functions of TCR and pre-TCR subunits: lessons from gene ablation

1996 • 77 citations

Regulation of AP-1 and NFAT Transcription Factors during Thymic Selection of T Cells

1996 • 74 citations

Cytokine production by mature and immature thymocytes.

1991 • 69 citations

Positive selection of CD4+ and CD8+ T cells

1996 • 55 citations

The Cyclosporin‐sensitive Transcription Factor NFATp Is Expressed in Several Classes of Cells in the Immune System^a

1995 • 54 citations

Control of NFATx1 Nuclear Translocation by a Calcineurin-Regulated Inhibitory Domain

1997 • 54 citations

Signaling mechanisms in T cells.

1991 • 53 citations

HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells.

1993 • 53 citations

Intracellular signaling events during positive and negative selection of CD4+CD8+ thymocytes in vitro.

1995 • 53 citations

Nuclear events after activation of CD4+8+ thymocytes.

1990 • 50 citations

Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression.

1997 • 47 citations

Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression.

1997 • 47 citations

Activation of the interleukin-4 gene is controlled by the unique calcineurin-dependent transcriptional factor NF(P).

1994 • 45 citations

Transcription Factor Activation during Signal-induced Apoptosis of Immature CD4+CD8+ Thymocytes

1997 • 41 citations

Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.

1997 • 34 citations

In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells.

1994 • 34 citations

Positive and negative selection of the αβ T-cell repertoire in vivo

1991 • 33 citations

Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

1993 • 30 citations

The Granulocyte-Macrophage Colony-Stimulating Factor Promoter cis-Acting Element CLE0 Mediates Induction Signals in T Cells and is Recognized by Factors Related to AP1 and NFAT

1993 • 30 citations

Nuclear factors that mediate intrathymic signals are developmentally regulated.

1994 • 27 citations

Purification of the 120-kDa Component of the Human Nuclear Factor of Activated T Cells (NF-AT): Reconstitution of Binding Activity to the cis-Acting Element of the GM-CSF and IL-2 Promoter with AP-1

1993 • 21 citations

Developmental control of antigen-induced thymic transcription factors

1996 • 14 citations