STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Calcium signalling: dynamics, homeostasis and remodelling

2003 • 5,215 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx

2005 • 2,020 citations

STIM1, an essential and conserved component of store-operated Ca2+ channel function

2005 • 1,757 citations

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 • 797 citations

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

2006 • 772 citations

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

2006 • 660 citations

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

2006 • 630 citations

Bcl-2-mediated alterations in endoplasmic reticulum Ca ²⁺ analyzed with an improved genetically encoded fluorescent sensor

2004 • 613 citations

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca ²⁺ store depletion

2007 • 592 citations

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

2006 • 576 citations

The unfolded protein response

2006 • 575 citations

Orai1 and STIM Reconstitute Store-operated Calcium Channel Function

2006 • 547 citations

SERCA pump isoforms: Their role in calcium transport and disease

2007 • 538 citations

Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1

2006 • 537 citations

Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region

2006 • 382 citations

Calcium and Arrhythmogenesis

2007 • 341 citations

Deranged neuronal calcium signaling and Huntington disease

2004 • 253 citations

Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum

2006 • 248 citations

STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Ca2+ Entry

2006 • 241 citations

Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing

2003 • 210 citations

Calcium leak from intracellular stores—the enigma of calcium signalling

2002 • 187 citations

Exporting calcium from cells

2005 • 159 citations

Plasma Membrane Ca2+ ATPases as Dynamic Regulators of Cellular Calcium Handling

2007 • 149 citations

Ryanodine receptor 1 mutations, dysregulation of calcium homeostasis and neuromuscular disorders

2005 • 136 citations

The Na⁺/Ca²⁺ Exchange Molecule

2002 • 111 citations

Biochemical properties and cellular localisation of STIM proteins

2007 • 107 citations

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons

2007 • 104 citations

Rapid Turnover of Calcium in the Endoplasmic Reticulum during Signaling

2000 • 95 citations

Targeted recombinant aequorins: Tools for monitoring [Ca2+] in the various compartments of a living cell

1999 • 92 citations

Calcium, protease activation, and cytoskeleton remodeling underlie growth cone formation and neuronal regeneration.

2001 • 79 citations

Mitochondrial Ca2+ homeostasis in health and disease

2004 • 52 citations

Stabilizing Role of Calcium Store-Dependent Plasma Membrane Calcium Channels in Action-Potential Firing and Intracellular Calcium Oscillations

2005 • 30 citations

Calcium channel blockers, endothelial dysfunction, and combination therapy.

2005 • 29 citations

Epithelial Ca2+ and Mg2+ Channels in Kidney Disease

2006 • 24 citations

Stimulation by thimerosal of histamine-induced Ca2+release in intact HeLa cells seen with aequorin targeted to the endoplasmic reticulum

2001 • 22 citations