Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Genesis: cluster analysis of microarray data

2002 • 1,737 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

T cell killing does not require the formation of a stable mature immunological synapse

2004 • 569 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Negative selection — clearing out the bad apples from the T-cell repertoire

2003 • 494 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Identification of a Naturally Occurring Ligand for Thymic Positive Selection

1997 • 193 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

The timing of TCRα expression critically influences T cell development and selection

2005 • 179 citations

Lymphocyte calcium signaling from membrane to nucleus

2005 • 177 citations

In vivo thymocyte maturation. BUdR labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model.

1986 • 124 citations

A requirement for sustained ERK signaling during thymocyte positive selectionin vivo

2005 • 120 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

2004 • 96 citations

Distinct Signals Mediate Maturation and Allelic Exclusion in Lymphocyte Progenitors

1999 • 89 citations

Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection

2004 • 79 citations

Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca2+-Dependent Transcriptional Induction of Bim

2006 • 68 citations

TOX Provides a Link Between Calcineurin Activation and CD8 Lineage Commitment

2004 • 66 citations

Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes.

1993 • 61 citations

Selective Role of NFATc3 in Positive Selection of Thymocytes

2007 • 46 citations