Structurally delineating stromal interaction molecules as the endoplasmic reticulum calcium sensors and regulators of calcium release‐activated calcium entry

Clustal W and Clustal X version 2.0

2007 • 27,119 citations

The PyMOL Molecular Graphics System

2002 • 18,218 citations

The versatility and universality of calcium signalling

2000 • 5,407 citations

Calcium signalling: dynamics, homeostasis and remodelling

2003 • 5,215 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

Store-Operated Calcium Channels

2005 • 2,077 citations

STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx

2005 • 2,020 citations

STIM1, an essential and conserved component of store-operated Ca2+ channel function

2005 • 1,757 citations

Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding

1995 • 1,706 citations

The interaction of a naphthalene dye with apomyoglobin and apohemoglobin

1965 • 1,486 citations

Dali: a network tool for protein structure comparison

1995 • 1,447 citations

Calmodulin: a prototypical calcium sensor

2000 • 1,445 citations

Store depletion and calcium influx

1997 • 1,422 citations

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

2005 • 1,358 citations

Orai1 is an essential pore subunit of the CRAC channel

2006 • 1,305 citations

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

2006 • 1,285 citations

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

1992 • 1,258 citations

Capacitative calcium entry

1995 • 1,112 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

Calcium signalling in lymphocyte activation and disease

2007 • 990 citations

The endoplasmic reticulum: a multifunctional signaling organelle

2002 • 948 citations

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

2009 • 897 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

Genome-wide RNAi screen of Ca ²⁺ influx identifies genes that regulate Ca ²⁺ release-activated Ca ²⁺ channel activity

2006 • 838 citations

A novel approach for sequential assignment of proton, carbon-13, and nitrogen-15 spectra of larger proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin

1990 • 836 citations

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 • 797 citations

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

2006 • 772 citations

Calcium binding and conformational response in EF-hand proteins

1996 • 650 citations

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

2007 • 649 citations

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

2009 • 644 citations

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

2006 • 630 citations

STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels

2006 • 627 citations

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca ²⁺ store depletion

2007 • 592 citations

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

2006 • 576 citations

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

2008 • 573 citations

CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

2006 • 555 citations

Orai1 and STIM Reconstitute Store-operated Calcium Channel Function

2006 • 547 citations

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

2008 • 538 citations

Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1

2006 • 537 citations

Calmodulin target database.

2000 • 534 citations

EF-hand calcium-binding proteins

2000 • 507 citations

Calcium binding to calmodulin and its globular domains

1991 • 486 citations

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

2008 • 433 citations

THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION.

1965 • 423 citations

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

2008 • 403 citations

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

2008 • 387 citations

Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region

2006 • 382 citations

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

2008 • 380 citations

Biochemical and Functional Characterization of Orai Proteins

2007 • 375 citations

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

2009 • 312 citations

STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction

2008 • 302 citations

STIM1 has a plasma membrane role in the activation of store-operated Ca ²⁺ channels

2006 • 302 citations

Coupling of STIM1 to store-operated Ca ²⁺ entry through its constitutive and inducible movement in the endoplasmic reticulum

2006 • 300 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 294 citations

Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

2008 • 286 citations

A New Protein Factor Promoting Aggregation of Tropomyosin

1965 • 281 citations

The Many Faces of SAM

2005 • 276 citations

Diversity of conformational states and changes within the EF-hand protein superfamily

1999 • 267 citations

Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: Two ways to promote multifunctionality

2006 • 261 citations

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation

2008 • 255 citations

SAM domains: uniform structure, diversity of function

2003 • 253 citations

Functional stoichiometry of the unitary calcium-release-activated calcium channel

2008 • 249 citations

Visualization and Manipulation of Plasma Membrane-Endoplasmic Reticulum Contact Sites Indicates the Presence of Additional Molecular Components within the STIM1-Orai1 Complex

2007 • 247 citations

STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Ca2+ Entry

2006 • 241 citations

Mapping the Interacting Domains of STIM1 and Orai1 in Ca2+ Release-activated Ca2+ Channel Activation

2007 • 237 citations

Oligomeric Structure of the Human EphB2 Receptor SAM Domain

1999 • 233 citations

The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.

1999 • 233 citations

STIM1: a novel phosphoprotein located at the cell surface

2000 • 231 citations

TRPC channels function independently of STIM1 and Orai1

2009 • 227 citations

A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

2005 • 225 citations

Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1

2006 • 225 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 221 citations

Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels

2008 • 218 citations

STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy

2008 • 214 citations

TRPC channels as STIM1-regulated store-operated channels

2007 • 214 citations

The SAM domain of polyhomeotic forms a helical polymer.

2002 • 212 citations

Structures of EF-hand Ca(2+)-binding proteins: diversity in the organization, packing and response to Ca2+ binding.

1998 • 207 citations

Interaction of STIM1 with Endogenously Expressed Human Canonical TRP1 upon Depletion of Intracellular Ca2+ Stores

2006 • 207 citations

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

2007 • 206 citations

The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators

2003 • 204 citations

Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3

2008 • 183 citations

STIM1 regulates Ca²⁺ entry via arachidonate‐regulated Ca²⁺‐selective (ARC) channels without store depletion or translocation to the plasma membrane

2006 • 181 citations

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

1995 • 174 citations

Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+ Entry (SOCE)

2008 • 173 citations

Ca2+-store-dependent and -independent reversal of Stim1 localization and function

2008 • 172 citations

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

2008 • 171 citations

STIM and Orai: the long-awaited constituents of store-operated calcium entry

2009 • 167 citations

Calmodulin Mediates Calcium-Dependent Inactivation of the Cerebellar Type 1 Inositol 1,4,5-Trisphosphate Receptor

1999 • 164 citations

New molecular players in capacitative Ca2+ entry

2007 • 158 citations

Both Orai1 and Orai3 are essential components of the arachidonate‐regulated Ca²⁺‐selective (ARC) channels

2007 • 156 citations

STIM2 protein mediates distinct store‐dependent and store‐independent modes of CRAC channel activation

2007 • 155 citations

Store-operated cyclic AMP signalling mediated by STIM1

2009 • 153 citations

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

2008 • 147 citations

Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation

2002 • 144 citations

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

2008 • 144 citations

Collapse and cooperativity in protein folding

1996 • 131 citations

Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1

2007 • 124 citations

Physiological Roles Of The Ca2+/Cam-Dependent Protein kinase Cascade In Health and Disease

2007 • 121 citations

Regulation of Gli1 Localization by the cAMP/Protein Kinase A Signaling Axis through a Site Near the Nuclear Localization Signal

2005 • 120 citations

Arachidonic acid, ARC channels, and Orai proteins

2009 • 104 citations

Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

2002 • 98 citations

Orai, STIM1 and iPLA₂β: a view from a different perspective

2008 • 87 citations

Binding of the C-terminal Sterile α Motif (SAM) Domain of Human p73 to Lipid Membranes

2003 • 81 citations

Calcium signals mediated by STIM and Orai proteins—A new paradigm in inter-organelle communication

2006 • 81 citations

Novel Role for STIM1 as a Trigger for Calcium Influx Factor Production

2008 • 80 citations

Capacitative Ca²⁺Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

2009 • 74 citations

Calmodulin Binding to the Polybasic C-Termini of STIM Proteins Involved in Store-Operated Calcium Entry

2008 • 68 citations

STIM1 and the noncapacitative ARC channels

2007 • 60 citations

Hydrogen bonding in the carboxyl-terminal half-fragment 78-148 of calmodulin as studied by two-dimensional nuclear magnetic resonance

1985 • 60 citations

Molecular Evolution and Functional Divergence of the Ca2+ Sensor Protein in Store-operated Ca2+ Entry: Stromal Interaction Molecule

2007 • 45 citations

Vector Geometry Mapping: A Method to Characterize the Conformation of Helix-Loop-Helix Calcium-Binding Proteins

2003 • 43 citations

Sequence‐specific assignments of downfield‐shifted amide proton resonances of calmodulin Use of two‐dimensional NMR analysis of its tryptic fragments

1987 • 36 citations

Calcium-binding proteins and the EF-hand principle

2007 • 30 citations

Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans

2007 • 27 citations

Lifting the fog in store-operated Ca2+ entry

2005 • 20 citations

Crystallization and characterization of Smaug: a novel RNA-binding motif

2002 • 9 citations

The unusual history and unique properties of the calcium signal

2007 • 9 citations

Defective transmembrane calcium influx demonstrated in a primary immunodeficiency by video-imaging.

1994 • 6 citations

Structural aspects of calcium-binding proteins and their interactions with targets

2007 • 3 citations

STIM1 tracks growing microtubule ends

2008 • 2 citations