Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

Store-Operated Calcium Channels

2005 • 2,077 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

NFAT proteins: key regulators of T-cell development and function

2005 • 1,434 citations

Orai1 is an essential pore subunit of the CRAC channel

2006 • 1,305 citations

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

2006 • 1,285 citations

Genome-wide RNAi screen of Ca ²⁺ influx identifies genes that regulate Ca ²⁺ release-activated Ca ²⁺ channel activity

2006 • 838 citations

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 • 797 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

Regulation of mast-cell and basophil function and survival by IgE

2002 • 626 citations

CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

2006 • 555 citations

New developments in FcεRI regulation, function and inhibition

2007 • 541 citations

How Synaptotagmin Promotes Membrane Fusion

2007 • 536 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

Synaptotagmin: A Ca2+ sensor that triggers exocytosis?

2002 • 464 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Biochemical and Functional Characterization of Orai Proteins

2007 • 375 citations

CRACM1, CRACM2, and CRACM3 Are Store-Operated Ca2+ Channels with Distinct Functional Properties

2007 • 369 citations

Emerging Roles of Presynaptic Proteins in Ca ⁺⁺ -Triggered Exocytosis

2002 • 319 citations

The ins and outs of IgE-dependent mast-cell exocytosis

2004 • 316 citations

Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane

1994 • 305 citations

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

2003 • 247 citations

Calcium Inhibition and Calcium Potentiation of Orai1, Orai2, and Orai3 Calcium Release-activated Calcium Channels

2007 • 236 citations

125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells.

1987 • 214 citations

The role of NF-AT transcription factors in T cell activation and differentiation11We dedicate this review to Prof. Dr. Rigomar Rieger (Gatersleben), a great scientist and man, on the occasion of his 70th birthday. One of us (E.S.) had the pleasure of working in his department.

2000 • 203 citations

Functional Co-localization of Transfected Ca2+-stimulable Adenylyl Cyclases with Capacitative Ca2+ Entry Sites

1996 • 168 citations

Calcium oscillations in T-cells: mechanisms and consequences for gene expression

2003 • 154 citations

Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells

2003 • 141 citations

SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF-κB Activity

2002 • 137 citations

Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings

1996 • 127 citations

Capacitative calcium entry supports calcium oscillations in human embryonic kidney cells

2004 • 124 citations

Dependence of the Ca2+-inhibitable Adenylyl Cyclase of C6–2B Glioma Cells on Capacitative Ca2+ Entry

1998 • 114 citations

Ca2+ influx through CRAC channels activates cytosolic phospholipase A₂, leukotriene C₄secretion, and expression of c‐fos through ERK‐dependent and independent pathways in mast cells

2006 • 99 citations

Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines

2006 • 96 citations

Close Functional Coupling between Ca2+ Release-activated Ca2+ Channels, Arachidonic Acid Release, and Leukotriene C4 Secretion

2004 • 84 citations

Capacitative Ca2+ entry regulates Ca2+-sensitive adenylyl cyclases

1994 • 82 citations

[35] Gene trapping methods for the identification and functional analysis of cell surface proteins in mice

2000 • 75 citations

Negative Regulation of FcεRI-mediated Degranulation by CD81

1997 • 66 citations

Secretory responses of rat peritoneal mast cells to high intracellular calcium

1988 • 61 citations