TRPM channels, calcium and redox sensors during innate immune responses

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

Poly(ADP-ribose): novel functions for an old molecule

2006 • 1,827 citations

AN INTRODUCTION TO TRP CHANNELS

2005 • 1,512 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

2006 • 1,285 citations

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

1994 • 998 citations

The TRP Superfamily of Cation Channels

2005 • 980 citations

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

2001 • 900 citations

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

2001 • 877 citations

LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death

2002 • 794 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

A Key Role for TRPM7 Channels in Anoxic Neuronal Death

2003 • 770 citations

TRP channels: An overview

2005 • 721 citations

TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

2001 • 714 citations

TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization

2002 • 700 citations

Orai1 and STIM Reconstitute Store-operated Calcium Channel Function

2006 • 547 citations

Mechanisms of capacitative calcium entry

2001 • 536 citations

TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions

2002 • 489 citations

Connexin 43 hemichannels mediate Ca2+‐regulated transmembrane NAD+ fluxes in intact cells

2000 • 450 citations

Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo

2001 • 448 citations

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion

2006 • 438 citations

Immunocyte Ca ²⁺ Influx System Mediated by LTRPC2

2001 • 434 citations

Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

1998 • 398 citations

Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels

2004 • 357 citations

Activation of the Cation Channel Long Transient Receptor Potential Channel 2 (LTRPC2) by Hydrogen Peroxide

2002 • 344 citations

TRPM7, a novel regulator of actomyosin contractility and cell adhesion

2006 • 338 citations

Tissue Distribution Profiles of the Human TRPM Cation Channel Family

2006 • 336 citations

Cyclic ADP-Ribose and Hydrogen Peroxide Synergize with ADP-Ribose in the Activation of TRPM2 Channels

2005 • 326 citations

Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains

2006 • 320 citations

TRPM4 Regulates Calcium Oscillations After T Cell Activation

2004 • 319 citations

Human CD38, a cell‐surface protein with multiple functions

1996 • 303 citations

Regulation of the Ca2+ Sensitivity of the Nonselective Cation Channel TRPM4

2004 • 284 citations

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

2004 • 273 citations

Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia

2004 • 273 citations

The TRPM ion channel subfamily: molecular, biophysical and functional features

2004 • 272 citations

Critical Intracellular Ca2+ Dependence of Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel Activation

2003 • 270 citations

Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release

1993 • 259 citations

Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain

1998 • 255 citations

Synthesis and Degradation of Cyclic ADP-Ribose by NAD Glycohydrolases

1993 • 246 citations

TRP channels: a TR(I)P through a world of multifunctional cation channels

2005 • 241 citations

Mediation of cell death by poly(ADP-ribose) polymerase-1

2005 • 240 citations

A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death

2003 • 228 citations

TRPM7 Regulates Cell Adhesion by Controlling the Calcium-dependent Protease Calpain

2006 • 226 citations

Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform

2001 • 226 citations

Hydroperoxide-induced loss of pyridine nucleotides and release of calcium from rat liver mitochondria.

1980 • 220 citations

Melastatin Expression and Prognosis in Cutaneous Malignant Melanoma

2001 • 219 citations

A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide

2006 • 215 citations

Transcriptional Regulation of the Melanoma Prognostic Marker Melastatin (TRPM1) by MITF in Melanocytes and Melanoma

2004 • 212 citations

Regulation of Dendritic Cell Trafficking by the ADP-Ribosyl Cyclase CD38

2004 • 201 citations

Inhibitor and NAD⁺ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling^,

1998 • 196 citations

Involvement of TRPM7 in Cell Growth as a Spontaneously Activated Ca2+ Entry Pathway in Human Retinoblastoma Cells

2004 • 181 citations

Dissociation of the store‐operated calcium current I_CRAC and the Mg‐nucleotide‐regulated metal ion current MagNuM

2002 • 180 citations

Distinct Properties of CRAC and MIC Channels in RBL Cells

2002 • 179 citations

TRPM7 Channel Is Regulated by Magnesium Nucleotides via its Kinase Domain

2006 • 178 citations

TRPM2 Ca2+ permeable cation channels: from gene to biological function

2003 • 173 citations

The Role of TRP Channels in Oxidative Stress-induced Cell Death

2006 • 171 citations

Nicotinic acid adenine dinucleotide phosphate and cyclic ADP‐ribose regulate TRPM2 channels in T lymphocytes

2006 • 168 citations

TRPMs and neuronal cell death

2005 • 153 citations

Intracellular nucleotides and polyamines inhibit the Ca 2+ -activated cation channel TRPM4b

2004 • 151 citations

Elongation factor‐2 kinase and its newly discovered relatives

2002 • 148 citations

Inhibition of TRPM2 cation channels by N‐(p‐amylcinnamoyl)anthranilic acid

2006 • 147 citations

Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole

2004 • 147 citations

Poly-ADP-ribosylation in health and disease

2005 • 146 citations

The Selectivity Filter of the Cation Channel TRPM4

2005 • 145 citations

C-terminal domains implicated in the functional surface expression of potassium channels

2003 • 143 citations

Flufenamic acid is a pH-dependent antagonist of TRPM2 channels

2004 • 139 citations

Regulation of a TRPM7-like Current in Rat Brain Microglia

2003 • 138 citations

CD38: a new paradigm in lymphocyte activation and signal transduction

1998 • 137 citations

Modulation of Calcium Signaling by Interleukin-13 in Human Airway Smooth Muscle

2004 • 133 citations

Nicotinic acid–adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor

2002 • 132 citations

TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage

2005 • 126 citations

TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose

2005 • 122 citations

The role of TRPM channels in cell death

2005 • 121 citations

Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death

2005 • 120 citations

Polyvalent Cations as Permeant Probes of MIC and TRPM7 Pores

2003 • 117 citations

Ecto-ADP-Ribosyltransferases (ARTs): Emerging Actors in Cell Communication and Signaling

2004 • 113 citations

NUDT9, a Member of the Nudix Hydrolase Family, Is an Evolutionarily Conserved Mitochondrial ADP-ribose Pyrophosphatase

2003 • 112 citations

CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle

2005 • 111 citations

Structure and Enzymology of ADP-ribosyl Cyclases: Conserved Enzymes that Produce Multiple Calcium Mobilizing Metabolites

2004 • 107 citations

Ligand‐induced internalization of CD38 results in intracellular Ca²⁺mobilization: role of NAD⁺transport across cell membranes

1999 • 107 citations

Magnitude and significance of NAD turnover in human cell line D98/AH2

1976 • 105 citations

Gallotannin Inhibits the Expression of Chemokines and Inflammatory Cytokines in A549 Cells

2005 • 102 citations

Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose

2004 • 102 citations

Mg2+ Homeostasis: The Mg2+nificent TRPM Chanzymes

2003 • 100 citations

TRP Genes

2002 • 95 citations

Ca2+ Entry Induced by Cyclic ADP-ribose in Intact T-Lymphocytes

1997 • 94 citations

Response to ADP-Ribose by Activation of TRPM2 in the CRI-G1 Insulinoma Cell Line

2003 • 92 citations

Patterns of melastatin mRNA expression in melanocytic tumors

2000 • 89 citations

Inhibitor‐induced structural change of the active site of human poly(ADP‐ribose) polymerase

2003 • 84 citations

Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions

2002 • 84 citations

Biochemistry, Biology, and Pharmacology of Cyclic Adenosine Diphosphoribose (cADPR)

2004 • 82 citations

Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes

2004 • 81 citations

The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death

2000 • 77 citations

Altered Airway Responsiveness in CD38-Deficient Mice

2004 • 77 citations

Novel aspects of signaling and ion-homeostasis regulation in immunocytesThe TRPM ion channels and their potential role in modulating the immune response

2004 • 76 citations

Characterization of human and mouse TRPM2 genes: Identification of a novel N-terminal truncated protein specifically expressed in human striatum

2005 • 75 citations

Altered TRPC7 gene expression in bipolar-I disorder

2001 • 74 citations

Calcium antagonists and vasodilation

1994 • 73 citations

Oxidative stress‐induced death in the nervous system: Cell cycle dependent or independent?

2004 • 70 citations

Equilibrative and Concentrative Nucleoside Transporters Mediate Influx of Extracellular Cyclic ADP-Ribose into 3T3 Murine Fibroblasts

2002 • 69 citations

Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii

2005 • 68 citations

Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity

2003 • 68 citations

TRPM7 and Ischemic CNS Injury

2005 • 67 citations

Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte

2006 • 66 citations

TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors

2005 • 61 citations

Knock-down of the Type 3 Ryanodine Receptor Impairs Sustained Ca2+ Signaling via the T Cell Receptor/CD3 Complex

2002 • 59 citations

Turnover of nicotinamide adenine dinucleotide in cultures of human cells

1976 • 57 citations

Cyclic ADP-Ribose and NAADP

2002 • 55 citations

Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. part 4: Biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries

2003 • 55 citations

Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and Cell Function

2002 • 55 citations

Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice

2004 • 53 citations

Sensitivity of mitochondrial peptidyl-prolyl cis-trans isomerase, pyridine nucleotide hydrolysis and Ca2+ release to cyclosporine a and related compounds

1993 • 47 citations

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function

2006 • 46 citations

Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools

2004 • 45 citations

Pyridine nucleotide metabolism in mammalian cells in culture

1973 • 42 citations

Chemistry of Cyclic ADP-Ribose and its Analogs

2004 • 42 citations

Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target

2005 • 40 citations

Role of poly(ADP-ribose) glycohydrolase (PARG) in shock, ischemia and reperfusion

2005 • 36 citations

Concentrative Influx of Functionally Active Cyclic ADP-ribose in Dimethyl Sulfoxide-differentiated HL-60 Cells

2004 • 33 citations

Identification of an Inhibitor Binding Site of Poly(ADP-ribose) Glycohydrolase

2003 • 30 citations

Topology of CD38

2000 • 30 citations

Role of CD38 in myometrial Ca²⁺transients: modulation by progesterone

2004 • 27 citations

NAADP: A New Second Messenger Comes of Age

2005 • 24 citations

Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes

2006 • 17 citations

The TRPM Cation Channels in the Immune Context

2005 • 17 citations

Mechanisms of Calcium Signaling and Function in Lymphocytes

2006 • 16 citations

Inositol 1,4,5-Trisphosphate and its Co-players in the Concert of Ca2+ Signalling - New Faces in the Line Up

2004 • 13 citations

Regulation of Immune Responses by CD38 and cADPR

2002 • 4 citations

Cyclic ADP-ribose and NAADP

2003 • 4 citations

Perivascular localization of TRPM1- and TRPM2-positive cells in the rat brain.

1996 • 2 citations

Inward currents and increases in cytosolic Ca2+ concentration induced by cyclic ADP-ribose in turtle olfactory receptor cells

2003 • 1 citations