A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

1988 • 1,777 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

The T Cell Antigen Receptor: Insights into Organelle Biology

1990 • 361 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Lymphocyte membrane potential assessed with fluorescent probes

1980 • 336 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Calcium and T lymphocyte activation

1989 • 246 citations

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

1993 • 242 citations

Primary Immunodeficiency Caused by Mutations in the Gene Encoding the CD3-γ Subunit of the T-Lymphocyte Receptor

1992 • 225 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1

1991 • 201 citations

Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry.

1993 • 183 citations

Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate

1991 • 182 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

T cell activation via CD2 [T, gp50] molecules: accessory cells are required to trigger T cell activation via CD2-D66 plus CD2-9.6/T11(1) epitopes.

1985 • 150 citations

Severe Combined Immunodeficiency Due to a Specific Defect in the Production of Interleukin-2

1990 • 146 citations

Calcium fluxes in T lymphocytes.

1992 • 133 citations

Independent mutations of the human CD3–ε gene resulting in a T cell receptor/CD3 complex immunodeficiency

1993 • 125 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor

1991 • 113 citations

Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.

1993 • 112 citations

Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

1993 • 104 citations

The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations

1987 • 103 citations

Evidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes.

1992 • 95 citations

Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.

1992 • 91 citations

An Immunodeficiency Characterized by Defective Signal Transduction in T Lymphocytes

1989 • 88 citations

Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells.

1990 • 78 citations

Impaired metabolic function and signaling defects in phagocytic cells in glycogen storage disease type 1b.

1990 • 62 citations

Immunodeficiency with low expression of the T cell receptor/CD3 complex. Effect on T lymphocyte activation

1991 • 60 citations

Role of membrane potential in the response of human T lymphocytes to phytohemagglutinin.

1987 • 60 citations

Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relations to AIDS

1988 • 55 citations

Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes.

1990 • 55 citations

Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency.

1993 • 41 citations

Functional roles of ion channels in lymphocytes.

1990 • 36 citations

Membrane depolarization selectively inhibits receptor-operated calcium channels in human T (Jurkat) lymphoblasts

1990 • 35 citations

Signaling requirements for the expression of the transactivating factor NF‐AT in human T lymphocytes

1991 • 31 citations

Immunodeficiency with defective T-cell response to interleukin 1.

1984 • 27 citations

The T Cell Antigen Receptor: Insights Into Organelle Biology

1990 • 20 citations

Correlation between interleukin-1 production and engraftment of transplanted bone marrow stem cells in patients with lethal immunodeficiencies

1989 • 15 citations

Defective membrane function in a patient with severe combined immunodeficiency disease.

1980 • 12 citations

Abnormal Signal Transduction in a Patient with Severe Combined Immunodeficiency Disease

1991 • 9 citations