Biochemical and Functional Characterization of Orai Proteins

A model for receptor-regulated calcium entry

1986 • 2,535 citations

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 • 2,174 citations

STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx

2005 • 2,020 citations

Transcriptional regulation by calcium, calcineurin, and NFAT

2003 • 1,893 citations

STIM1, an essential and conserved component of store-operated Ca2+ channel function

2005 • 1,757 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

2005 • 1,358 citations

Orai1 is an essential pore subunit of the CRAC channel

2006 • 1,305 citations

CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca ²⁺ Entry

2006 • 1,285 citations

Calcium Signaling Mechanisms in T Lymphocytes

2001 • 841 citations

Genome-wide RNAi screen of Ca ²⁺ influx identifies genes that regulate Ca ²⁺ release-activated Ca ²⁺ channel activity

2006 • 838 citations

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 • 797 citations

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

2006 • 772 citations

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

2006 • 630 citations

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

2006 • 576 citations

Gene regulation mediated by calcium signals in T lymphocytes

2001 • 572 citations

CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

2006 • 555 citations

Orai1 and STIM Reconstitute Store-operated Calcium Channel Function

2006 • 547 citations

Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1

2006 • 537 citations

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

2006 • 383 citations

Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region

2006 • 382 citations

pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

1998 • 341 citations

Functional Analysis of a Human Homologue of the Drosophila Actin Binding Protein Anillin Suggests a Role in Cytokinesis

2000 • 301 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 294 citations

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays

2006 • 286 citations

Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1

2006 • 225 citations

A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

2005 • 225 citations

Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins

2001 • 221 citations

Ca2+/calcineurin signalling in cells of the immune system

2003 • 177 citations

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

2004 • 114 citations

Feo, the Drosophila Homolog of PRC1, Is Required for Central-Spindle Formation and Cytokinesis

2004 • 110 citations

Role of the store‐operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor‐stimulated calcium oscillations in human embryonic kidney cells

2007 • 104 citations

FlyRNAi: the Drosophila RNAi screening center database

2005 • 88 citations

High-Throughput RNA Interference Screens in Drosophila Tissue Culture Cells

2005 • 77 citations

Transformation of human T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells.

1993 • 75 citations