HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1996 • 1,660 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Vasculogenesis

1995 • 1,344 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein

1995 • 1,028 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Identification of neurogenin, a Vertebrate Neuronal Determination Gene

1996 • 821 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possibleIn vivo regulatory mechanisms

1994 • 464 citations

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

1996 • 412 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

1996 • 287 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.

1996 • 264 citations

Tubulogenesis in Drosophila: a requirement for the trachealess gene product.

1996 • 264 citations

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix-Loop-Helix/PAS Factor (Arnt2) with Close Sequence Similarity to the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt)

1996 • 261 citations

MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation

1996 • 237 citations

Overexpression of Vascular Endothelial Growth Factor in the Avian Embryo Induces Hypervascularization and Increased Vascular Permeability without Alterations of Embryonic Pattern Formation

1995 • 222 citations

Paraxis: A Basic Helix-Loop-Helix Protein Expressed in Paraxial Mesoderm and Developing Somites

1995 • 203 citations

The role of vascular endothelial growth factor in blood vessel formation

1996 • 163 citations

Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia

1996 • 162 citations

Wiring diagrams: regulatory circuits and the control of skeletal myogenesis

1994 • 154 citations

Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis

1996 • 139 citations

Nucleotide Sequence, Chromosomal Assignment and mRNA Expression of Mouse Hypoxia-Inducible Factor-1α

1996 • 123 citations

Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo

1995 • 97 citations

Development of a sensitive reverse transcriptase PCR assay, RT-RPCR, utilizing rapid cycle times.

1992 • 72 citations

Salivary duct determination in Drosophila: roles of the EGF receptor signaling pathway and the transcription factors Fork head and Trachealess

1996 • 68 citations

Expression of C-ETS1 in Early Chick Embryo Mesoderm: Relationship to the Hemangioblastic Lineage

1993 • 60 citations

Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites.

1994 • 54 citations

cDNA Cloning of a Murine Homologue ofDrosophilaSingle-Minded, Its mRNA Expression in Mouse Development, and Chromosome Localization

1996 • 49 citations

Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development.

1995 • 46 citations