The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

1994 • 449 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements

1987 • 323 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).

1994 • 249 citations

Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.

1993 • 207 citations

Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene

1995 • 199 citations

Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.

1979 • 191 citations

Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini.

1994 • 160 citations

Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups

1983 • 124 citations

Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells

1993 • 120 citations

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

1994 • 101 citations

Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes.

1994 • 83 citations

Mechanism of Action of a Repressor of Dioxin-Dependent Induction of Cyplal Gene Transcription

1992 • 54 citations

Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines

1994 • 46 citations

A genetic analysis of processes regulating cytochrome P4501A1 expression

1994 • 24 citations

Isolation and Characterization of Revertants from Four Different Classes of Aryl Hydrocarbon Hydroxylase-Deficient Hepa-1 Mutants

1984 • 21 citations