Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

1992 • 811 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

1994 • 669 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

Inhibition of NF- B DNA Binding by Nitric Oxide

1996 • 479 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

The regulated expression of erythropoietin by two human hepatoma cell lines.

1987 • 374 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Reciprocal relation between VEGF and NO in the regulation of endothelial integrity

1997 • 367 citations

Cooperativity in the dissociation of nitric oxide from hemoglobin.

1976 • 289 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 271 citations

Anemia induces accumulation of erythropoietin mRNA in the kidney and liver.

1986 • 237 citations

Induction of myocardial nitric oxide synthase by cardiac allograft rejection.

1994 • 212 citations

The Complex Role of Nitric Oxide in the Pathophysiology of Focal Cerebral Ischemia

1994 • 176 citations

A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt.

1993 • 150 citations

Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage

1991 • 131 citations

Regulatory DNA elements localized remotely upstream from the drug-metabolizing cytochrome P-450c gene

1986 • 128 citations

Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts

1990 • 113 citations

Real time measurement of nitric oxide produced ex vivo by luminol-H2O2 chemiluminescence method.

1993 • 102 citations

Cellular euthanasia mediated by a nuclear enzyme: a central role for nuclear ADP-ribosylation in cellular metabolism

1987 • 101 citations

Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation

1994 • 97 citations

Poly(ADP‐ribose) polymerase: Molecular biological aspects

1991 • 95 citations

Inadequate erythropoietin response to anemia: definition and clinical relevance

1994 • 86 citations

Anemia Induces Accumulation of Erythropoietin mRNA in the Kidney and Liver

1986 • 57 citations

Nitric oxide ferrohemes: kinetics of formation and photodissociation quantum yields

1983 • 52 citations