Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Expression monitoring by hybridization to high-density oligonucleotide arrays

1996 • 2,796 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS

1998 • 526 citations

Propagation in a Fluid Medium of a Human Epidermoid Carcinoma, Strain KB

1955 • 490 citations

Claudins regulate the intestinal barrier in response to immune mediators

2000 • 438 citations

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

1999 • 388 citations

Perspectives on Oxygen Sensing

1999 • 376 citations

Oxygen Sensing, Hypoxia-Inducible Factor-1 and the Regulation of Mammalian Gene Expression

1998 • 362 citations

Hypoxia‐induced activation of HIF‐1: role of HIF‐1α‐Hsp90 interaction

1999 • 309 citations

Neutrophil-derived 5′-Adenosine Monophosphate Promotes Endothelial Barrier Function via CD73-mediated Conversion to Adenosine and Endothelial A2B Receptor Activation

1998 • 225 citations

Trefoil peptides: from structure to function

1997 • 217 citations

Distinct Pathways of Cell Migration and Antiapoptotic Response to Epithelial Injury: Structure-Function Analysis of Human Intestinal Trefoil Factor

2000 • 205 citations

Structural Analysis of a Human Intestinal Epithelial Cell Line

1987 • 193 citations

Growth Factors in Inflammatory Bowel Disease

1999 • 179 citations

Intestinal trefoil factor controls the expression of the adenomatous polyposis coli–catenin and the E-cadherin–catenin complexes in human colon carcinoma cells

1998 • 151 citations

Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia

2000 • 132 citations

Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes

1997 • 103 citations

Macrovascular and microvascular endothelium during long‐term hypoxia: Alterations in cell growth, monolayer permeability, and cell surface coagulant properties

1991 • 95 citations

Epithelial exposure to hypoxia modulates neutrophil transepithelial migration.

1996 • 95 citations

Critical Role of cAMP Response Element Binding Protein Expression in Hypoxia-elicited Induction of Epithelial Tumor Necrosis Factor-α

1999 • 91 citations

Knowledge discovery in gene-expression-microarray data: mining the information output of the genome

1999 • 82 citations

THE IMPACT OF FEMUR FRACTURE WITH ASSOCIATED SOFT TISSUE INJURY ON IMMUNE FUNCTION AND INTESTINAL PERMEABILITY

1996 • 77 citations

Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.

1996 • 68 citations

Carboxyl-terminal Vesicular Stomatitis Virus G Protein-tagged Intestinal Na+-dependent Glucose Cotransporter (SGLT1)

1996 • 65 citations

Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells

1998 • 63 citations

Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine

1997 • 53 citations

INTESTINAL EPITHELIAL HYPERPERMEABILITY

1998 • 51 citations

Therapeutic targets for hypoxia-elicited pathways.

1999 • 45 citations

Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene

2000 • 41 citations

Identification of a Goblet Cell-specific Enhancer Element in the Rat Intestinal Trefoil Factor Gene Promoter Bound by a Goblet Cell Nuclear Protein

1998 • 40 citations

HIF-1, a Mediator of the Molecular Response to Hypoxia

1997 • 38 citations

X. Trefoil peptide and EGF receptor/ligand transgenic mice

2000 • 32 citations

NG-monomethyl-l-arginine inhibits erythropoietin gene expression by stimulating GATA-2

2000 • 31 citations

Isolation and characterization of the apical surface of polarized Madin-Darby canine kidney epithelial cells.

1988 • 29 citations

Characterization of the Genomic Structure and the Promoter Region of the Human Intestinal Trefoil Factor

1995 • 20 citations

Intestinal Epithelial Hyperpermeability

1997 • 15 citations

Parallel induction of epithelial surface-associated chemokine and proteoglycan by cellular hypoxia: implications for neutrophil activation

2000 • 12 citations

Lessons from genetically engineered animal models X. Trefoil peptide and EGF receptor/ligand transgenic mice.

2000 • 9 citations