Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

The AH-receptor: genetics, structure and function

1993 • 437 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1995 • 388 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

Mechanistic aspects of dioxin action

1993 • 372 citations

Identification of Functional Domains of the Aryl Hydrocarbon Receptor

1995 • 322 citations

Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).

1994 • 249 citations

Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription

1996 • 245 citations

Molecular biology of the aromatic hydrocarbon (dioxin) receptor

1994 • 234 citations

Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.

1983 • 232 citations

Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.

1993 • 207 citations

Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.

1983 • 200 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function

1995 • 180 citations

Dioxin-Induced CYP1A1 Transcription In Vivo: the Aromatic Hydrocarbon Receptor Mediates Transactivation, Enhancer-Promoter Communication, and Changes in Chromatin Structure

1996 • 161 citations

Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation.

1994 • 160 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.

1993 • 160 citations

Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini.

1994 • 160 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

1992 • 126 citations

Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line

1995 • 119 citations

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

1994 • 101 citations

Organization and function of a dioxin-responsive enhancer.

1990 • 99 citations

Orientation of the heterodimeric aryl hydrocarbon (dioxin) receptor complex on its asymmetric DNA recognition sequence.

1995 • 97 citations

The Potential Role of DNA Methylation in the Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1989 • 89 citations

Dioxin Induces Localized, Graded Changes in Chromatin Structure: Implications forCyp1A1Gene Transcription

1995 • 89 citations

DNA Binding by the Heterodimeric Ah Receptor

1996 • 86 citations

Transcriptional Activation by the Mouse Ah Receptor.

1995 • 80 citations

Gene Expression in Low Oxygen Tension

1993 • 79 citations

Transcriptional activation domains of the Ah receptor and Ah receptor nuclear translocator

1995 • 57 citations