Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Angiogenesis.

1992 • 2,581 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.

1995 • 1,021 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

1991 • 932 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Erythropoietin

1991 • 852 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis on a primate model

1994 • 584 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes

1995 • 453 citations

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

1994 • 430 citations

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1995 • 388 citations

The Mouse Gene for Vascular Endothelial Growth Factor

1996 • 335 citations

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

1993 • 308 citations

Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes

1995 • 300 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

1991 • 260 citations

Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).

1994 • 249 citations

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

1993 • 239 citations

Regulation of Vascular Endothelial Growth Factor in Cardiac Myocytes

1995 • 212 citations

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene

1991 • 209 citations

Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events

1991 • 202 citations

In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction

1993 • 198 citations

Hypoxia regulatory elements of the human vascular endothelial growth factor gene.

1994 • 196 citations

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.

1995 • 190 citations

Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure

1989 • 170 citations

VEGF/VPF: The angiogenesis factor found?

1993 • 163 citations

Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation.

1994 • 160 citations

Hypoxia-Induced Transcription of the Vascular Endothelial Growth Factor Gene Is Independent of Functional Ap-1 Transcription Factor

1995 • 132 citations

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.

1993 • 131 citations

Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells

1993 • 120 citations

Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line

1995 • 119 citations

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

1994 • 101 citations

Molecular biology of erythropoietin

1993 • 84 citations

Transcriptional Activation by the Mouse Ah Receptor.

1995 • 80 citations

Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys

1991 • 31 citations