Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

1996 • 1,031 citations

Erythropoietin

1991 • 852 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]

1992 • 612 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Effect of inflammatory cytokines on hypoxia-induced erythropoietin production

1992 • 518 citations

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1998 • 506 citations

Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]

1992 • 475 citations

Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1

1997 • 400 citations

Proinflammatory Cytokines Lowering Erythropoietin Production

1998 • 397 citations

The regulated expression of erythropoietin by two human hepatoma cell lines.

1987 • 374 citations

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells

1995 • 347 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site

1995 • 228 citations

Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta.

1997 • 226 citations

Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys

1992 • 209 citations

The Orphan Receptor Hepatic Nuclear Factor 4 Functions as a Transcriptional Activator for Tissue-Specific and Hypoxia-Specific Erythropoietin Gene Expression and Is Antagonized by EAR3/COUP-TF1

1995 • 200 citations

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

1997 • 197 citations

Pericellular PO2 and O2 consumption in monolayer cell cultures

1995 • 154 citations

Hypoxia and the regulation of gene expression

1998 • 127 citations

Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line

1995 • 119 citations

Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats

1997 • 100 citations

Microelectrode measurements of pericellular PO2 in erythropoietin-producing human hepatoma cell cultures

1993 • 72 citations

The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive

1997 • 59 citations

Positive and negative regulation of the erythropoietin gene.

1994 • 40 citations

Distinct Signaling Pathways Mediate Phorbol‐Ester‐Induced and Cytokine‐Induced Inhibition of Erythropoietin Gene Expression

1994 • 40 citations

Oxygen sensing and response to hypoxia by mammalian cells

1996 • 34 citations

The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5' flanking region

1993 • 33 citations

Erythropoietin gene expression by hydrogen peroxide.

1996 • 21 citations

Co-Transactivation of the 3′ Erythropoietin Hypoxia Inducible Enhancer by the HIF-1 Protein

1997 • 19 citations

Tumor necrosis factor p55 receptor (TNF-RI) mediates the in vitro inhibition of hepatic erythropoietin production

1999 • 14 citations