Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

Current protocols in molecular biology

1988 • 7,584 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

Circadian oscillation of a mammalian homologue of the Drosophila period gene

1997 • 782 citations

An essential role for p300/CBP in the cellular response to hypoxia

1996 • 780 citations

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

1997 • 778 citations

A new class of yeast transcriptional activators

1987 • 706 citations

RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

1997 • 664 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

1997 • 605 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Neurospora wc-1 and wc-2 : Transcription, Photoresponses, and the Origins of Circadian Rhythmicity

1997 • 494 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

The Hypoxic Response: Huffing and HIFing

1997 • 482 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

1997 • 406 citations

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1995 • 388 citations

Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.

1996 • 376 citations

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1998 • 347 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

1994 • 308 citations

Nucleocytoplasmic shuttling of the progesterone receptor.

1991 • 296 citations

Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor

1998 • 275 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals.

1987 • 263 citations

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

1992 • 242 citations

Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells.

1995 • 240 citations

Trafficking of the androgen receptor in living cells with fused green fluorescent protein–androgen receptor

1997 • 197 citations

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.

1995 • 190 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 177 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

1993 • 161 citations

Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import

1996 • 157 citations

The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system.

1994 • 151 citations

The PAS domain confers target gene specificity of DrosophilabHLH/PAS proteins

1997 • 138 citations

A Nuclear Localization Signal of Human Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor 1β Is a Novel Bipartite Type Recognized by the Two Components of Nuclear Pore-targeting Complex

1997 • 121 citations

Heat shock protein hsp90 regulates dioxin receptor function in vivo.

1995 • 120 citations

Constitutive Function of the Basic Helix-Loop-Helix/PAS Factor Arnt.

1995 • 99 citations

Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis

1998 • 86 citations

Regulation of transcription factor localization: fine-tuning of gene expression

1996 • 47 citations

Mechanism of Signal Transduction by the basic Helix-Loop-Helix Dioxin Receptor

1995 • 32 citations

Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis

1998 • 3 citations