The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1α (HIF-1α) and Inhibits HIF-1-mediated Transcription

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Oncogenic alterations of metabolism

1999 • 1,095 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

The ARF/p53 pathway

2000 • 647 citations

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

2000 • 641 citations

Frequent Co‐Alterations of TP53, p16/CDKN2A, p14^ARF, PTEN Tumor Suppressor Genes in Human Glioma Cell Lines.

1999 • 539 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1997 • 514 citations

Suppression of tumor growth through disruption of hypoxia-inducible transcription

2000 • 501 citations

p53-independent functions of the p19^ARF tumor suppressor

2000 • 356 citations

Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

2000 • 345 citations

Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

2000 • 287 citations

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription

1998 • 284 citations

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

2000 • 281 citations

Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex

2000 • 274 citations

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

1996 • 240 citations

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.

1998 • 231 citations

The nucleolus: the magician’s hat for cell cycle tricks

2000 • 195 citations

Identification of a cryptic nucleolar-localization signal in MDM2

2000 • 186 citations

p19ARF targets certain E2F species for degradation

2001 • 177 citations