Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

Oxidative Stress as a Regulator of Gene Expression in the Vasculature

1999 • 810 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells

2000 • 465 citations

Mammalian Oxygen Sensing, Signalling and Gene Regulation

2000 • 453 citations

Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation

2000 • 399 citations

ERK activation upon hypoxia: involvement in HIF‐1 activation

2000 • 365 citations

Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin

1999 • 332 citations

p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts

1998 • 321 citations

Transforming growth factor-alpha -induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation

1997 • 256 citations

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1999 • 243 citations

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

2000 • 237 citations

Differential Activation of Mitogen-Activated Protein Kinases in Smooth Muscle Cells by Angiotensin II

2000 • 218 citations

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.

1997 • 203 citations

Redox-regulated Signaling by Lactosylceramide in the Proliferation of Human Aortic Smooth Muscle Cells

1997 • 202 citations

A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor

2000 • 177 citations

Induction of Vascular Endothelial Growth Factor in Balloon-Injured Baboon Arteries

1997 • 158 citations

Cell Mediated Events that Control Blood Coagulation and Vascular Injury

1993 • 138 citations

Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells

1991 • 133 citations

Platelet-Derived Growth Factor-BB and Thrombin Activate Phosphoinositide 3-Kinase and Protein Kinase B: Role in Mediating Airway Smooth Muscle Proliferation

1998 • 123 citations

Early Wound Healing Exhibits Cytokine Surge Without Evidence of Hypoxia

2000 • 119 citations

Inhibitors of Fibrinolysis Are Elevated in Atherosclerotic Plaque

1996 • 114 citations

Modulation of the Glucagon-Dependent Induction of Phosphoenolpyruvate Carboxykinase and Tyrosine Aminotransferase by Arterial and Venous Oxygen Concentrations in Hepatocyte Cultures

1981 • 106 citations

Oxidative stress and expression of p22phox are involved in the up‐regulation of tissue factor in vascular smooth muscle cells in response to activated platelets

2000 • 105 citations

Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver

2001 • 103 citations

Redox Signals that Regulate the Vascular Response to Injury

1999 • 89 citations

Plasminogen Activator Inhibitor Type 1 and Tissue Inhibitor of Metalloproteinases-2 Increase After Arterial Injury in Rats

1997 • 84 citations

Induction of Plasminogen Activator Inhibitor Type 1 and Type 1 Collagen Expression in Rat Cardiac Microvascular Endothelial Cells by Interleukin-1 and Its Dependence on Oxygen-Centered Free Radicals

1998 • 84 citations

Accelerated Endothelialization by Local Delivery of Recombinant Human Vascular Endothelial Growth Factor Reduces In-Stent Intimal Formation

1997 • 82 citations

Thrombin-induced MCP-1 Expression Involves Activation of the p22phox-containing NADPH Oxidase in Human Vascular Smooth Muscle Cells

2001 • 74 citations

Thrombin Stimulates Expression of Tissue-Type Plasminogen Activator and Plasminogen Activator lnhibitor Type 1 in Cultured Human Vascular Smooth Muscle Cells

1993 • 68 citations

Local Plasminogen Activator Inhibitor Type 1 Overexpression in Rat Carotid Artery Enhances Thrombosis and Endothelial Regeneration While Inhibiting Intimal Thickening

2000 • 59 citations

Aggregating Human Platelets Stimulate the Expression of Thrombin Receptors in Cultured Vascular Smooth Muscle Cells via the Release of Transforming Growth Factor-β ₁ and Platelet-Derived Growth Factor _AB

1997 • 50 citations

Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products.

1995 • 39 citations

Aggregating Human Platelets Stimulate Expression of Vascular Endothelial Growth Factor in Cultured Vascular Smooth Muscle Cells Through a Synergistic Effect of Transforming Growth Factor-β ₁ and Platelet-Derived Growth Factor _AB

1999 • 34 citations

Vascular endothelial growth factor (VEGF) expression during arterial repair in the pig

1998 • 23 citations