Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Microsomes and drug oxidation

1969 • 451 citations

Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*

1987 • 409 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product

1988 • 353 citations

Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements

1987 • 323 citations

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

1984 • 278 citations

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.

1982 • 269 citations

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

1988 • 268 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.

1988 • 198 citations

Binding of heat shock proteins to the avian progesterone receptor.

1989 • 192 citations

Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.

1979 • 191 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.

1987 • 167 citations

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

1982 • 160 citations

Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line.

1985 • 124 citations

Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups

1983 • 124 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors in wild type and variant mouse hepatoma cells. Nuclear location and strength of nuclear binding.

1984 • 120 citations

Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

1989 • 111 citations

Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.

1986 • 102 citations

In situ localization of the per clock protein during development of Drosophila melanogaster.

1988 • 101 citations

Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes

1990 • 100 citations

Characterization of multiple forms of the Ah receptor: comparison of species and tissues

1989 • 85 citations

The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. A comparison with the glucocorticoid receptor and the mouse and rat hepatic dioxin receptors.

1987 • 79 citations

The murine Ah locus: a new allele and mapping to chromosome 12.

1987 • 78 citations

A method for measuring the non-random bias of a codon usage table

1984 • 66 citations

Profile scanning for three-dimensional structural patterns in protein sequences

1988 • 60 citations

Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450

1989 • 59 citations

Hepatocarcinogenic heterocyclic aromatic amines that induce cytochrome P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in rat liver

1989 • 56 citations

Interindividual and intraindividual variations in aryl hydrocarbon hydroxylase in monocytes from monozygotic and dizygotic twins.

1977 • 54 citations

The 1982 Bernard B. brodie Award Lecture. Metabolism of Aromatic hydrocarbons by the cytochrome P-450 system and epoxide hydrolase.

1983 • 53 citations

Evidence that benzo(a)pyrene-resistant, aryl hydrocarbon hydroxylase-deficient variants of mouse hepatoma line, Hepa-1, are mutational in origin

1981 • 52 citations

Purification of the Ah receptor from C57BL/6J mouse liver.

1988 • 52 citations

Aryl hydrocarbon (Ah) receptor DNA-binding activity. Sequence specificity and Zn2+ requirement.

1990 • 49 citations

Ah receptor for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

1986 • 43 citations

Analysis of steroid resistance in lymphoid cell hybrids

1980 • 34 citations

Intracellular location of the Ah receptor

1986 • 32 citations

Selective Mutagenic Activation by Cytochrome P3-450 of Carcinogenic Arylamines Found in Foods

1989 • 32 citations

A third genetic locus affecting the Ah (dioxin) receptor.

1988 • 30 citations

Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase.

1983 • 23 citations

Transfection by Genomic DNA of Cytochrome P₁-450 Enzymatic Activity and Inducibility

1985 • 22 citations

Preferential induction of the rat hepatic P450 I proteins by the food carcinogen 2‐amino‐3‐methyl‐imidazo[4,5‐f]quinoline

1989 • 12 citations