The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

AH RECEPTOR SIGNALING PATHWAYS

1996 • 898 citations

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

1992 • 811 citations

Profound neuronal plasticity in response to inactivation of the dopamine transporter

1998 • 702 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Noradrenaline is essential for mouse fetal development

1995 • 534 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

1995 • 441 citations

Death before birth: clues from gene knockouts and mutations

1995 • 373 citations

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

1997 • 368 citations

trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.

1996 • 264 citations

Tubulogenesis in Drosophila: a requirement for the trachealess gene product.

1996 • 264 citations

Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice

1995 • 220 citations

Regulation of Tyrosine Hydroxylase Gene Expression in the Rat Carotid Body by Hypoxia

1992 • 186 citations

Transduction of chemostimuli by the type I carotid body cell

1995 • 137 citations

Fetal catecholamines

1983 • 64 citations

New models in vogue for circadian clocks

1995 • 44 citations

The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver

1993 • 23 citations

Regulation of Ionic Conductances and Gene Expression by Hypoxia in an Oxygen Sensitive Cell Line

1996 • 17 citations

[Functional organization of the autonomic nervous system].

1983 • 2 citations