Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

Functional neurogenesis in the adult hippocampus

2002 • 2,813 citations

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030

2006 • 2,214 citations

Learning enhances adult neurogenesis in the hippocampal formation

1999 • 2,134 citations

Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

1997 • 1,880 citations

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

2001 • 1,554 citations

Transient expression of doublecortin during adult neurogenesis

2003 • 1,485 citations

Milestones of neuronal development in the adult hippocampus

2004 • 1,389 citations

Neurogenesis in the Neocortex of Adult Primates

1999 • 1,268 citations

Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

1997 • 1,206 citations

Induction of neurogenesis in the neocortex of adult mice

2000 • 1,201 citations

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

2006 • 992 citations

Increased hippocampal neurogenesis in Alzheimer's disease

2003 • 955 citations

Doublecortin expression levels in adult brain reflect neurogenesis

2005 • 942 citations

The stress system in the human brain in depression and neurodegeneration

2005 • 912 citations

Dopamine depletion impairs precursor cell proliferation in Parkinson disease

2004 • 905 citations

Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

2007 • 863 citations

A Neurovascular Niche for Neurogenesis after Stroke

2006 • 846 citations

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory

1999 • 840 citations

Stem cells for the treatment of neurological disorders

2006 • 805 citations

Hippocampal neurogenesis in adult Old World primates

1999 • 804 citations

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

1997 • 789 citations

Continuation of neurogenesis in the hippocampus of the adult macaque monkey

1999 • 765 citations

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

2006 • 668 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

2004 • 638 citations

How widespread is adult neurogenesis in mammals?

2007 • 634 citations

Potential role for adult neurogenesis in the encoding of time in new memories

2006 • 631 citations

Short‐term and long‐term survival of new neurons in the rat dentate gyrus

2003 • 616 citations

Evidence for stroke-induced neurogenesis in the human brain

2006 • 604 citations

Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis

2000 • 598 citations

Evidence for neurogenesis in the adult mammalian substantia nigra

2003 • 577 citations

Cellular and molecular mechanisms of neural repair after stroke: Making waves

2006 • 564 citations

Aging Results in Reduced Epidermal Growth Factor Receptor Signaling, Diminished Olfactory Neurogenesis, and Deficits in Fine Olfactory Discrimination

2004 • 541 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

Is there a link between adult neurogenesis and learning?

2006 • 529 citations

Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

2003 • 510 citations

Neurogenesis in Adult Mammals: Some Progress and Problems

2002 • 509 citations

Limits of Neurogenesis in Primates

1985 • 486 citations

Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms

2005 • 485 citations

Importance of newly generated neurons in the adult olfactory bulb for odor discrimination

2000 • 484 citations

Neurogenesis in adult primate neocortex: an evaluation of the evidence

2002 • 480 citations

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

2007 • 476 citations

Time course of early motor and neuropathological anomalies in a knock‐in mouse model of Huntington's disease with 140 CAG repeats

2003 • 470 citations

Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease

2003 • 468 citations

Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

2005 • 461 citations

Newly generated neurons in the amygdala and adjoining cortex of adult primates

2002 • 459 citations

Social isolation delays the positive effects of running on adult neurogenesis

2006 • 452 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential

2002 • 443 citations

Neocortical neurogenesis in humans is restricted to development

2006 • 434 citations

Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis

2007 • 424 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

The generation, migration, and differentiation of olfactory neurons in the adult primate brain

2001 • 416 citations

What causes the hippocampal volume decrease in depression?

2007 • 401 citations

Chronic stress: Implications for neuronal morphology, function and neurogenesis

2007 • 367 citations

The dementias

2002 • 359 citations

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease

2006 • 355 citations

Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy

2005 • 353 citations

Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat

1998 • 352 citations

A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade

2004 • 352 citations

Injury-Induced Neurogenesis in the Adult Mammalian Brain

2003 • 343 citations

Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus

2006 • 312 citations

Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activation

2003 • 311 citations

Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults

2004 • 295 citations

Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells

2005 • 293 citations

Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell

2001 • 289 citations

Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus

2004 • 289 citations

Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus

2006 • 284 citations

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

2006 • 283 citations

Hippocampal Apoptosis in Major Depression Is a Minor Event and Absent from Subareas at Risk for Glucocorticoid Overexposure

2001 • 281 citations

Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

2004 • 278 citations

Kindling-induced neurogenesis in the dentate gyrus of the rat

1998 • 264 citations

Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy

2004 • 264 citations

Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path

1998 • 263 citations

Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat

1998 • 261 citations

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

2003 • 260 citations

Alterations of neuroplasticity in depression: the hippocampus and beyond

2004 • 259 citations

Seizures Accelerate Functional Integration of Adult-Generated Granule Cells

2006 • 256 citations

Olfactory Discrimination Learning Increases the Survival of Adult-Born Neurons in the Olfactory Bulb

2006 • 252 citations

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus

2001 • 247 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date

2003 • 241 citations

Activation of DNA Methyltransferase 1 by EBV LMP1 Involves c-Jun NH2-Terminal Kinase Signaling

2006 • 231 citations

Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis

2007 • 227 citations

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

1997 • 227 citations

Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress

2007 • 225 citations

Huntington's Disease

2007 • 219 citations

Temporally Specific Burst in Cell Proliferation Increases Hippocampal Neurogenesis in Protracted Abstinence from Alcohol

2004 • 219 citations

Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease

2006 • 213 citations

Adult-Born and Preexisting Olfactory Granule Neurons Undergo Distinct Experience-Dependent Modifications of their Olfactory ResponsesIn Vivo

2005 • 206 citations

Transgenic models of Alzheimer’s disease: Learning from animals

2005 • 206 citations

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

2005 • 204 citations

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis

2003 • 198 citations

Lifelong corticosterone level determines age-related decline in neurogenesis and memory

2005 • 196 citations

Dopamine and adult neurogenesis

2006 • 186 citations

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

2004 • 183 citations

VEGF‐overexpressing transgenic mice show enhanced post‐ischemic neurogenesis and neuromigration

2007 • 182 citations

Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment

2006 • 168 citations

Molecular neuroanatomy

1974 • 166 citations

Long-Lasting Regeneration After Ischemia in the Cerebral Cortex

2006 • 166 citations

Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors α and β

2006 • 165 citations

Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons

2005 • 163 citations

Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice

2007 • 162 citations

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice

2005 • 160 citations

Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy

2005 • 160 citations

Improved Long-Term Potentiation and Memory in Young Tau-P301L Transgenic Mice before Onset of Hyperphosphorylation and Tauopathy

2006 • 160 citations

Repairing brain after stroke: A review on post-ischemic neurogenesis

2007 • 159 citations

Fibroblast Growth Factor Receptor-1 is Required for Long-Term Potentiation, Memory Consolidation, and Neurogenesis

2007 • 156 citations

Alcohol and adult neurogenesis: Roles in neurodegeneration and recovery in chronic alcoholism

2006 • 156 citations

Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb

2005 • 155 citations

Decreased hippocampal cell proliferation in R6/1 Huntington’s mice

2004 • 150 citations

Human Wild-Type α-Synuclein Impairs Neurogenesis

2004 • 148 citations

Neuronal Cell Death in a Rat Model for Mesial Temporal Lobe Epilepsy Is Induced by the Initial Status Epilepticus and Not by Later Repeated Spontaneous Seizures

2003 • 144 citations

Voluntary exercise‐induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke

2007 • 144 citations

Perturbed Neurogenesis in the Adult Hippocampus Associated with Presenilin-1 A246E Mutation

2005 • 144 citations

Knock-in mouse models of Huntington’s disease

2005 • 138 citations

Increased number of neural progenitors in human temporal lobe epilepsy

2005 • 136 citations

Neural stem cells LewisX + CXCR4 + modify disease progression in an amyotrophic lateral sclerosis model

2007 • 134 citations

Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease

2006 • 123 citations

Abnormalities of Neurogenesis in the R6/2 Mouse Model of Huntington's Disease Are Attributable to theIn VivoMicroenvironment

2005 • 122 citations

Electroconvulsive Seizures Induce Angiogenesis in Adult Rat Hippocampus

2005 • 122 citations

Ki-67 Immunoreactivity in Alzheimerʼs Disease and Other Neurodegenerative Disorders

1995 • 118 citations

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis

2006 • 117 citations

Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin

2007 • 114 citations

Paradoxical effects of learning the Morris water maze on adult hippocampal neurogenesis in mice may be explained by a combination of stress and physical activity

2005 • 103 citations

Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease

2005 • 102 citations

Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease

2007 • 100 citations

Prolonged seizures recruit caudal subventricular zone glial progenitors into the injured hippocampus

2006 • 97 citations

Recovery and Rehabilitation in Stroke

2004 • 97 citations

Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

2007 • 92 citations

A natural form of learning can increase and decrease the survival of new neurons in the dentate gyrus

2005 • 87 citations

Fear learning transiently impairs hippocampal cell proliferation

2004 • 87 citations

Neurogenesis in adult primates

2002 • 76 citations

Moderate ethanol consumption increases hippocampal cell proliferation and neurogenesis in the adult mouse

2005 • 74 citations

Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews

2004 • 69 citations

Stem cell‐based therapy for Parkinson's disease

2005 • 67 citations

Tau‐4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/ knockout mice

2007 • 65 citations

The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain

2006 • 64 citations

Sensorimotor skill learning in amnesia: additional evidence for the neural basis of nondeclarative memory.

1994 • 64 citations

Alzheimer's Disease Neurofibrillary Tangles Contain Mitosis‐Specific Phosphoepitopes

1996 • 63 citations

Memory for spatial location in ‘de novo’ parkinsonian patients

1997 • 62 citations

Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?

2007 • 62 citations

Depression in Parkinson's disease. An update.

2001 • 54 citations

Induction of neuronal type-specific neurogenesis in the cerebral cortex of adult mice: manipulation of neural precursors in situ

2002 • 53 citations

The role of dopamine in the regulation of melatonin biosynthesis in vertebrate retina.

1994 • 50 citations

Formation of Tau Inclusions in Knock-in Mice with Familial Alzheimer Disease (FAD) Mutation of Presenilin 1 (PS1)

2005 • 50 citations

Diagnosis and treatment of Alzheimer's disease.

2003 • 49 citations

Proliferative status of cells in adult human dentate gyrus

1999 • 40 citations

Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease

2007 • 39 citations

Depression in Parkinson’s Disease

2004 • 39 citations

Transgenic mouse models for Alzheimer's disease: the role of GSK-3β in combined amyloid and tau-pathology

2006 • 38 citations

Low concentrations of extracellular FGF-2 are sufficient but not essential for neurogenesis from human neural progenitor cells

2006 • 31 citations

Neurogenesis in the Diseased Adult Human Brain: New Therapeutic Strategies for Neurodegenerative Diseases

2003 • 26 citations

Decreased proliferation in the adult rat hippocampus after exposure to the Morris water maze and its reversal by fluoxetine

2005 • 24 citations

Enhancing recognition of early Parkinsonism in the community

2004 • 20 citations

Neurogenesis in Diseases of the Central Nervous System

2006 • 15 citations

Postnatal development and sexual differentiation of pig hypothalamic nuclei

1994 • 14 citations

The second layer neurones of the entorhinal cortex and the perforant path in physiological ageing and Alzheimer's disease

1994 • 13 citations

A Review of the Non-Alzheimer Dementias

2006 • 11 citations

Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation

2008 • 6 citations

Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice

2004 • 4 citations

18 Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation

2008 • 2 citations

Deleted Work

1955 • 0 citations