Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

1996 • 1,734 citations

Tests for emotionality in rats and mice: A review

1973 • 1,561 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

2005 • 1,147 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Mice with Truncated MeCP2 Recapitulate Many Rett Syndrome Features and Display Hyperacetylation of Histone H3

2002 • 754 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

THE DECLINE OF WORKING MEMORY IN ALZHEIMER'S DISEASE

1991 • 684 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

Magnocellular nuclei of the basal forebrain project to neocortex, brain stem, and olfactory bulb. Review of some functional correlates

1975 • 482 citations

Spontaneous alternation behavior.

1958 • 471 citations

Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model

2004 • 396 citations

Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein

1999 • 378 citations

Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis

2004 • 366 citations

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

2000 • 355 citations

A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade

2004 • 352 citations

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein.

1995 • 333 citations

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40

2006 • 311 citations

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

1998 • 295 citations

Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

2004 • 278 citations

Changed Conformation of Mutant Tau-P301L Underlies the Moribund Tauopathy, Absent in Progressive, Nonlethal Axonopathy of Tau-4R/2N Transgenic Mice

2004 • 252 citations

Motor signs during the course of Alzheimer disease

2004 • 239 citations

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

2002 • 232 citations

Search Strategies Used byAPPTransgenic Mice During Navigation in the Morris Water Maze

2004 • 194 citations

Clioquinol down-regulates mutant huntingtin expressionin vitroand mitigates pathology in a Huntington's disease mouse model

2005 • 191 citations

A new continuous alternation task in T-maze detects hippocampal dysfunction in mice

1998 • 190 citations

Motor signs predict poor outcomes in Alzheimer disease

2005 • 190 citations

Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport

2001 • 176 citations

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors

2004 • 171 citations

Neural correlates of the motivational and somatic components of naloxone‐precipitated morphine withdrawal

2002 • 169 citations

Gait Disturbance in Alzheimer's Disease: A Clinical Study

1996 • 163 citations

Activity Level and Balance in Subjects with Mild Alzheimer’s Disease

2002 • 153 citations

Maintenance of balance, gait patterns, and obstacle clearance in Alzheimer's disease

1995 • 151 citations

Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord

2000 • 141 citations

Behavioral Assessment of Alzheimer's Transgenic Mice Following Long-Term Aβ Vaccination: Task Specificity and Correlations between Aβ Deposition and Spatial Memory

2001 • 130 citations

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease

2006 • 128 citations

Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation

2002 • 126 citations

Age-dependent axonal degeneration in an Alzheimer mouse model

2006 • 123 citations

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

2003 • 118 citations

Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice

2004 • 117 citations

Connexin30‐deficient mice show increased emotionality and decreased rearing activity in the open‐field along with neurochemical changes

2003 • 97 citations

Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

2005 • 92 citations

Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein

2004 • 85 citations

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

2003 • 83 citations

Impaired axonal transport of cortical neurons in Alzheimer’s disease is associated with neuropathological changes

2002 • 81 citations

Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease

2004 • 52 citations

Associative and motor learning in 12-month-old transgenic APP+PS1 mice

2005 • 47 citations

Motor performance and regional brain metabolism of spontaneous murine mutations with cerebellar atrophy

2001 • 27 citations

PS1 knockin mice with the Japanese I213T mutation: Effects on exploratory activity, motor coordination, and spatial learning

2005 • 8 citations