Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

The Ki-67 protein: From the known and the unknown

2000 • 4,426 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

1998 • 1,386 citations

Toxic Proteins in Neurodegenerative Disease

2002 • 1,202 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

2003 • 1,066 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease

2001 • 903 citations

Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles

2001 • 894 citations

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

1996 • 777 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

2003 • 664 citations

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

2003 • 632 citations

DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

2001 • 609 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1999 • 552 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells

1999 • 534 citations

Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration

2002 • 530 citations

Neurotrophins are required for nerve growth during development

2001 • 519 citations

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau

1997 • 517 citations

Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

2002 • 474 citations

Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease

2003 • 468 citations

Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404

1994 • 451 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1995 • 450 citations

Linking cyclins to transcriptional control

2002 • 434 citations

Disruption of Axonal Transport and Neuronal Viability by Amyloid Precursor Protein Mutations in Drosophila

2001 • 424 citations

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

1994 • 391 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase

1998 • 367 citations

Cell cycle markers in the hippocampus in Alzheimer's disease

1997 • 315 citations

Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family.

1989 • 306 citations

Conformational change as one of the earliest alterations of tau in Alzheimer's disease

2000 • 301 citations

Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains

2000 • 287 citations

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

2000 • 282 citations

Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach

2000 • 273 citations

Hypoxia-Ischemia Induces DNA Synthesis without Cell Proliferation in Dying Neurons in Adult Rodent Brain

2004 • 272 citations

Differential regulation of microtubule dynamics by three- and four-repeat tau: Implications for the onset of neurodegenerative disease

2003 • 253 citations

A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease

1997 • 247 citations

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

2001 • 219 citations

Alzheimer Disease

1998 • 211 citations

Apoptosis and Alzheimer's disease

2000 • 185 citations

Regional synaptic pathology in Alzheimer's disease

1992 • 176 citations

Kinetic Stabilization of Microtubule Dynamics at Steady State by Tau and Microtubule-Binding Domains of Tau

1995 • 174 citations

Frequency of Tau Gene Mutations in Familial and Sporadic Cases of Non-Alzheimer Dementia

2001 • 170 citations

Modulation of Microtubule Dynamics by Tau in Living Cells: Implications for Development and Neurodegeneration

2004 • 140 citations

Transient Cerebral Ischemia Induces Aberrant Neuronal Cell Cycle Re-entry and Alzheimer's Disease-like Tauopathy in Female Rats

2004 • 139 citations

Neuropathology in controls and demented subjects from the Baltimore longitudinal study of aging

1996 • 138 citations

DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology

1997 • 136 citations

Sequential Changes of Tau-Site-Specific Phosphorylation during Development of Paired Helical Filaments

1996 • 131 citations

Methods for the Detection of Apoptosis

1994 • 125 citations

Missense and splice site mutations in tau associated with FTDP-17: Multiple pathogenic mechanisms

2001 • 122 citations

Alkalinization of Acrosome Measured by GFP as a pH Indicator and Its Relation to Sperm Capacitation

2001 • 83 citations

Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease

2002 • 81 citations

Do Disorders of Movement Cause Movement Disorders and Dementia?

2003 • 80 citations

Tau Neurofibrillary Pathology and Microtubule Stability

2002 • 66 citations

Shrinkage necrosis of adrenal cortical cells

1972 • 59 citations

Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins

1999 • 46 citations

Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

2004 • 45 citations

The cell cycle and human neurodegenerative disease.

2003 • 42 citations

Sustained Activation of p34 Is Required for Noscapine-induced Apoptosis

2001 • 40 citations

Structure, function, and regulation of neuronal Cdc2-like protein kinase

1995 • 40 citations

PKA Phosphorylations on Tau: Developmental Studies in the Mouse

2000 • 33 citations

Pictures in Molecular Medicine: Contemplating Alzheimer's disease as cancer: a loss of cell-cycle control

2001 • 22 citations