Stem cells for the treatment of neurological disorders

Directed Differentiation of Embryonic Stem Cells into Motor Neurons

2002 • 1,723 citations

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury

2005 • 1,225 citations

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

1999 • 1,212 citations

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

2003 • 1,059 citations

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

2005 • 1,021 citations

Derivation of midbrain dopamine neurons from human embryonic stem cells

2004 • 981 citations

Stem cell therapy for human neurodegenerative disorders–how to make it work

2004 • 909 citations

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

2005 • 766 citations

Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice

2005 • 704 citations

Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke

2005 • 693 citations

Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

2005 • 618 citations

Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex

2004 • 616 citations

Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation

2004 • 613 citations

Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation

2004 • 572 citations

Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation

2004 • 567 citations

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation

2005 • 566 citations

Transplantation of in vitro‐expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

2002 • 533 citations

Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model

2005 • 478 citations

Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain

2003 • 441 citations

Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease

2005 • 421 citations

GDNF Delivery Using Human Neural Progenitor Cells in a Rat Model of ALS

2005 • 262 citations

Human Embryonic Germ Cell Derivatives Facilitate Motor Recovery of Rats with Diffuse Motor Neuron Injury

2003 • 252 citations

Factors affecting the clinical outcome after neural transplantation in Parkinson's disease

2005 • 250 citations

Human neural stem cell transplants improve motor function in a rat model of Huntington's disease

2004 • 240 citations

Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats

2004 • 232 citations

Functional Properties of Motoneurons Derived from Mouse Embryonic Stem Cells

2004 • 211 citations

Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia

2005 • 188 citations

Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

2004 • 176 citations

Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

2005 • 173 citations

Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury

2006 • 157 citations

Primate Embryonic Stem Cell-Derived Neuronal Progenitors Transplanted into Ischemic Brain

2006 • 131 citations

Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury

2005 • 78 citations