Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Neuronal replacement from endogenous precursors in the adult brain after stroke

2002 • 2,731 citations

Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain

1997 • 1,878 citations

Vascular niche for adult hippocampal neurogenesis

2000 • 1,805 citations

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

2004 • 1,498 citations

Inflammation is detrimental for neurogenesis in adult brain

2003 • 1,482 citations

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

2002 • 1,445 citations

Astroglia induce neurogenesis from adult neural stem cells

2002 • 1,422 citations

Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors

2002 • 1,419 citations

Neurogenesis in Adult Subventricular Zone

2002 • 1,415 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

For the Long Run

2004 • 1,289 citations

New roles for astrocytes: Redefining the functional architecture of the brain

2003 • 1,283 citations

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain

2000 • 1,218 citations

Irradiation induces neural precursor-cell dysfunction

2002 • 1,189 citations

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

2001 • 1,107 citations

Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

1995 • 1,102 citations

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

2001 • 1,048 citations

Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils

1998 • 1,031 citations

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

1996 • 1,027 citations

Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

2002 • 1,013 citations

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

2004 • 963 citations

Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus

2001 • 925 citations

Stem cell therapy for human neurodegenerative disorders–how to make it work

2004 • 909 citations

Isolation, Characterization, and use of Stem Cells from the CNS

1995 • 819 citations

VEGF links hippocampal activity with neurogenesis, learning and memory

2004 • 815 citations

Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms

2001 • 785 citations

Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis

1995 • 764 citations

In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain

1996 • 757 citations

Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

2004 • 756 citations

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

2002 • 701 citations

The migration of neuroblasts in the developing cerebral cortex.

1965 • 671 citations

Use of Tissue-Type Plasminogen Activator for Acute Ischemic Stroke

2000 • 665 citations

Modes of neuronal migration in the developing cerebral cortex

2002 • 660 citations

Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells

2001 • 649 citations

Regeneration of a germinal layer in the adult mammalian brain

1999 • 638 citations

Transplantation of cultured human neuronal cells for patients with stroke

2000 • 622 citations

Treatment of neural injury with marrow stromal cells

2002 • 621 citations

Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex

2004 • 616 citations

Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model

2004 • 602 citations

Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia

2001 • 568 citations

Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

2003 • 532 citations

Adenoviral Brain-Derived Neurotrophic Factor Induces Both Neostriatal and Olfactory Neuronal Recruitment from Endogenous Progenitor Cells in the Adult Forebrain

2001 • 531 citations

Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

2003 • 510 citations

Architecture and cell types of the adult subventricular zone: In search of the stem cells

1998 • 484 citations

FGF-2 regulation of neurogenesis in adult hippocampus after brain injury

2001 • 451 citations

Neurogenesis in adulthood: a possible role in learning

1999 • 422 citations

Direct Evidence for Homotypic, Glia-Independent Neuronal Migration

1997 • 410 citations

Chemokines and Their Receptors in the Central Nervous System

2001 • 402 citations

Correlation of VEGF and Angiopoietin Expression with Disruption of Blood–Brain Barrier and Angiogenesis after Focal Cerebral Ischemia

2002 • 391 citations

SDF-1 (CXCL12) Is Upregulated in the Ischemic Penumbra Following Stroke: Association with Bone Marrow Cell Homing to Injury

2004 • 385 citations

Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma

1999 • 384 citations

Postnatal Development of Radial Glia and the Ventricular Zone (VZ): a Continuum of the Neural Stem Cell Compartment

2003 • 376 citations

Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke in Rats

2002 • 372 citations

Activated Neural Stem Cells Contribute to Stroke-Induced Neurogenesis and Neuroblast Migration toward the Infarct Boundary in Adult Rats

2004 • 370 citations

Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis

1999 • 358 citations

Neurogenesis by Progenitor Cells in the Ischemic Adult Rat Hippocampus

2001 • 346 citations

Injury-Induced Neurogenesis in the Adult Mammalian Brain

2003 • 343 citations

Functional Recovery of Stroke Rats Induced by Granulocyte Colony-Stimulating Factor–Stimulated Stem Cells

2004 • 338 citations

Nitric oxide negatively regulates mammalian adult neurogenesis

2003 • 307 citations

In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain

1998 • 304 citations

Nitric Oxide Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and cGMP After Stroke in the Rat

2003 • 288 citations

Cortical Neurogenesis in Adult Rats After Transient Middle Cerebral Artery Occlusion

2001 • 253 citations

A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats

2001 • 251 citations

Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat

2001 • 245 citations

Nitric Oxide Is a Physiological Inhibitor of Neurogenesis in the Adult Mouse Subventricular Zone and Olfactory Bulb

2004 • 229 citations

Cell proliferation in the neural tube: An electron microscopic and Golgi analysis in the mouse cerebral vesicle

1971 • 227 citations

Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits

2004 • 217 citations

Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells

2004 • 216 citations

Expression of Inducible Nitric Oxide Synthase after Focal Cerebral Ischemia Stimulates Neurogenesis in the Adult Rodent Dentate Gyrus

2003 • 210 citations

Protein–Protein interactions, cytoskeletal regulation and neuronal migration

2001 • 203 citations

Proliferative characteristics of the ependymal layer during the early development of the mouse neocortex: a pilot study based on recording the number, location and plane of cleavage of mitotic figures.

1973 • 203 citations

Stroke Transiently Increases Subventricular Zone Cell Division from Asymmetric to Symmetric and Increases Neuronal Differentiation in the Adult Rat

2004 • 202 citations

Atorvastatin Reduces Neurological Deficit and Increases Synaptogenesis, Angiogenesis, and Neuronal Survival in Rats Subjected to Traumatic Brain Injury

2004 • 198 citations

Sphingosine‐1‐phosphate induces proliferation and morphological changes of neural progenitor cells

2004 • 195 citations

Functional Recovery in Aged and Young Rats After Embolic Stroke

2005 • 194 citations

Expression of Angiopoietin-1, Angiopoietin-2, and Tie Receptors after Middle Cerebral Artery Occlusion in the Rat

2000 • 194 citations

EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia

2003 • 192 citations

VEGF is a chemoattractant for FGF-2–stimulated neural progenitors

2003 • 191 citations

Chapter 1 The subventricular zone: source of neuronal precursors for brain repair

2000 • 187 citations

Neuronal Progenitor Cells Derived from the Anterior Subventricular Zone of the Neonatal Rat Forebrain Continue to Proliferatein Vitroand Express a Neuronal Phenotype

1997 • 181 citations

Neuroblasts of the postnatal mammalian forebrain: Their phenotype and fate

1998 • 181 citations

Magnetic resonance imaging and neurosphere therapy of stroke in rat

2003 • 175 citations

Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys

2003 • 164 citations

Transplantation of neural stem cells in a rat model of stroke: assessment of short-term graft survival and acute host immunological response

2002 • 145 citations

The cGMP-dependent protein kinase-gene, protein, and function

1993 • 143 citations

Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis

2004 • 136 citations

Induction of Angiopoietin and Tie Receptor mRNA Expression after Cerebral Ischemia–Reperfusion

2000 • 136 citations

Neurogenesis following brain ischemia

2002 • 133 citations

Akt-1 Expression Level Regulates CNS Precursors

2004 • 114 citations

Insights in Vessel Development and Vascular Disorders Using Targeted Inactivation and Transfer of Vascular Endothelial Growth Factor, the Tissue Factor Receptor, and the Plasminogen System

1997 • 113 citations

Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia

2002 • 107 citations

Akt Regulates Basic Helix-Loop-Helix Transcription Factor–Coactivator Complex Formation and Activity during Neuronal Differentiation

2003 • 106 citations

The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells

2001 • 106 citations

Three Steps of Neural Stem Cells Development in Gerbil Dentate Gyrus after Transient Ischemia

2002 • 97 citations

Epidermal growth factor receptor in proliferating reactive glia following transient focal ischemia in the rat brain

1998 • 95 citations

Post-ischemic Administration of Heparin-Binding Epidermal Growth Factor-like Growth Factor (HB-EGF) Reduces Infarct Size and Modifies Neurogenesis after Focal Cerebral Ischemia in the Rat

2004 • 95 citations

Temporal Profile of Stem Cell Division, Migration, and Differentiation from Subventricular Zone to Olfactory Bulb after Transient Forebrain Ischemia in Gerbils

2003 • 90 citations

Neurogenesis After Transient Global Ischemia in the Adult Hippocampus Visualized by Improved Retroviral Vector

2004 • 90 citations

Increased expression of basic fibroblast growth factor (bFGF) following focal cerebral infarction in the rat

1996 • 90 citations

Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury

1999 • 83 citations

Biology of erythropoietin

2001 • 81 citations

Changes in cognitive function after neuronal cell transplantation for basal ganglia stroke

2004 • 60 citations

Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve

1997 • 55 citations

Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat

2004 • 54 citations

Adenovirus-Mediated Gene Transfer of Fibroblast Growth Factor-2 Increases BrdU-Positive Cells After Forebrain Ischemia in Gerbils

2003 • 51 citations

Phosphoinositide 3‐kinase promotes adult subventricular neuroblast migration after stroke

2003 • 37 citations

Down-regulation of p27kip1 increases proliferation of progenitor cells in adult rats

2004 • 15 citations

Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila

2004 • 7 citations